Liver Regeneration

Basic Mechanisms, Relevant Models and Clinical Applications

Udayan M. Apte (Associate Professor, The University of Kansas Medical Center)

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Hardback

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English

Academic Press Inc
18 August 2015

Medical research; Hepatology

Liver Regeneration: Basic Mechanisms, Relevant Models and Clinical Applications presents cutting-edge information on liver regeneration research through an integrated, systems-wide perspective. The book addresses discoveries on hepatic progenitor cells, liver regeneration after chemical damage, and liver regeneration as a prime therapy for liver failure and disease.

By addressing the urgent need for translating basic research findings into clinically relevant modalities and potential therapeutic applications, the book provides the data needed to improve liver patient management.

Hundreds of full-color, graphic photographs and illustrations underline key elements and show researchers and students important aspects of liver transplantation, immunofluorescence, and other techniques used in liver regeneration.

Edited by: Udayan M. Apte (Associate Professor The University of Kansas Medical Center)
Imprint: Academic Press Inc
Country of Publication: United States
Dimensions: Height: 234mm, Width: 191mm, Spine: 23mm
Weight: 840g
ISBN: 9780124201286
ISBN 10: 0124201288
Pages: 326
Publication Date: 18 August 2015
Audience: Professional and scholarly , Undergraduate
Format: Hardback
Publisher's Status: Active

Chapter 1. Introduction to Liver Regeneration: History and General Principles Chapter 2. Models to Study Liver Regeneration Chapter 3. Alternative Models to Study Liver Regeneration: Zebrafish Chapter 4. The Priming and Progression Theory of Liver Regeneration Chapter 5. Primary and Secondary Mitogen Theory of Liver Regeneration Chapter 6. Developmental Pathways in Liver Regeneration Chapter 7. Mechanisms of Termination of Liver Regeneration Chapter 8. Modulation of Extracellular Matrix During Liver Regeneration Chapter 9. Role of Chemokines Chapter 10. Role of Nuclear Receptors Chapter 11. Role of Developmental Morphogens in Liver Regeneration Chapter 12. Regulation of Cell Cycle during Liver Regeneration Chapter 13. Role of microRNAs and Long Non-Coding RNAs in Liver Regeneration Chapter 14. Changes in Hepatocyte Ploidy during Liver Regeneration Chapter 15. Role of Endothelial Cells in Liver Regeneration Chapter 16. Use of Computational Biology, Omics Technologies to Understand Liver Regeneration Chapter 17. Mitogen Induced Cell Proliferation in the Liver Chapter 18. Effect of Nutritional Diversity on Liver Regeneration Chapter 19. Introduction of Hepatic Progenitor Cells Chapter 20. Cellular Transdifferentiation in the Liver Chapter 21. Activation of Hepatic Progenitor Cells in Liver Regeneration After Chemical Injury to the Liver Chapter 22. Hepatic Progenitor Cells and iPS Cells as a Source of Mature Hepatocytes Chapter 23. Progenitor Cell Transplantation: Experimental Models Chapter 24. Liver Regeneration as a Therapy for Acute Liver Failure Chapter 25. Liver Regeneration Following Liver Transplantation Chapter 26. Hepatocyte Transplantation Therapy Chapter 27. Liver Regeneration: The Biliary Perspective

Dr. Apte is a toxicologist and a liver pathobiologists. His research is focused on mechanisms of liver regeneration, drug-induced liver injury, pathogenesis of liver cancer and effects of perfluorinated chemicals on the liver. Dr. Apte teaches toxicology to graduate students and medical students, and serves as a course director for two main toxicology courses in his department. Dr. Apte is also a board certified toxicologist and is a member of the US EPA's Scientific Advisory Committee on Chemicals (SACC).