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Leukocyte Recruitment, Endothelial Cell Adhesion Molecules, and Transcriptional Control: Insights for Drug Discovery by Tucker Collins at Abbey's Bookshop,
Leukocyte Recruitment, Endothelial Cell Adhesion Molecules, and Transcriptional Control: Insights for...
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Tucker Collins

Leukocyte Recruitment, Endothelial Cell Adhesion Molecules, and Transcriptional Control

Insights for Drug Discovery

Tucker Collins

$370.95   $296.98

Hardback

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English
Kluwer Academic Publishers
30 November 2000
Pathology; Biochemical immunology
The localized attachment of circulating leukocytes to endothelium has been recognized as the cellular hallmark of the inflammatory response. This adhesive interaction, a necessary antecedent to the emigration of leukocytes from the blood into the tissues, is mediated by vascular adhesion molecules. This volume outlines some of the cellular and molecular mechanisms of inflammation with contributions from researchers. It provides an overview of three of these endothelial adhesion molecules, as examples of key mediators of leukocyte recruitment. It reviews the structure and regulation of these cell surface proteins and focus on the rapidly expanding field of transcriptional regulation of these inducible proteins, and closes with a discussion of drug discovery possibilities that target the regulation of leukocyte recruitment. This should will be of interest for any researchers, in academia or industry, looking for an overview of leukocyte recruitment or novel approaches to drug discovery.
Edited by:  
Imprint:   Kluwer Academic Publishers
Country of Publication:   United States [Currently unable to ship to USA: see Shipping Info]
Edition:   2001 ed.
Dimensions:   Height: 235mm,  Width: 155mm,  Spine: 20mm
Weight:   1.470kg
ISBN:   9780792372233
ISBN 10:   0792372239
Pages:   327
Publication Date:  
Audience:   College/higher education ,  Professional and scholarly ,  Professional & Vocational ,  A / AS level ,  Further / Higher Education
Format:   Hardback
Publisher's Status:   Active
1. The Selectins in Leukocyte Recruitment.- 2. Transcriptional Regulation of the E-Selectin Gene.- 3. The Immunoglobulin Superfamily in Leukocyte Recruitment.- 4. Regulation of Intercellular Adhesion Molecule (ICAM) Gene Expression.- 5. Transcriptional Regulation of VCAM-1.- 6. Activation of Nuclear Factor-KB.- 7. The Basal Transcriptional Apparatus.- 8. Therapeutic Regulation of Leukocyte Adhesion Molecule Expression.- 9. The NF-kB System and Drug Discovery.

Reviews for Leukocyte Recruitment, Endothelial Cell Adhesion Molecules, and Transcriptional Control: Insights for Drug Discovery

Won Highly Commended in the Neurology category of the 2004 British Medical Association Library Book Competition.


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