Juvenile hormones (JHs) are a group of structurally related sesquiterpenes secreted by the insect corpora allata. They affect most insect life-cycle stages and physiological functions, including embryogenesis, larval and adult development, metamorphosis, reproduction, metabolism, diapause, polyethism, and migration. Juvenoids such as methoprene, hydroprene, kinoprene, pyriproxyfen, and fenoxycarb are man-made chemicals that mimic the structure and/or activity of JHs, selectively targeting and disrupting the endocrine system of insects. They are particularly suited as larvicides for the control of pest and disease vectoring insects such as mosquitoes.
Juvenile Hormones and Juvenoids: Modeling Biological Effects and Environmental Fate discusses the various modeling approaches that can be used to study the mechanism of action of JHs in insects and to estimate the adverse effects and the environmental fate of the juvenoids that mimic their activity. This book is the third of the QSAR in Environmental and Health Sciences series, but the first dedicated to the use of QSAR and other in silico techniques to provide these insights into JHs and their analogs.
With contributions by an international team of scientists, the book begins with a historical survey of JHs and juvenoids. It then discusses biosynthesis of sesquiterpenoids followed by chapters covering JH activity such as morph-specific JH titers in crickets, and JH analog activity including soldier-specific organ development in termites and the role of methoprene in gene transcription. The book examines modeling approaches applied to resistance to JH analogs, to population dynamics of nontarget species in the presence of juvenoids, and to SAR and QSAR of JH mimics. The book concludes with a discussion on the use of multicriteria analysis for selecting insecticides for vector control.
Juvenile Hormones and Juvenoids: A Historical Survey James Devillers Future Perspectives for Research on the Biosynthesis of Juvenile Hormones and Related Sesquiterpenoids in Arthropod Endocrinology and Ecotoxicology Jerome H.L. Hui, William G. Bendena, and Stephen S. Tobe Morph-Specific JH Titer Regulation in Wing-Polymorphic Gryllus Crickets: Proximate Mechanisms Underlying Adaptive Genetic Modification of JH Regulation Anthony J. Zera Soldier-Specific Organ Developments Induced by a Juvenile Hormone Analog in a Nasute Termite Kouhei Toga and Kiyoto Maekawa Roles of Juvenile Hormone Analog Methoprene in Gene Transcription Xiao-Fan Zhao Modeling Resistance to Juvenile Hormone Analogs: Linking Evolution, Ecology, and Management David W. Crowder, Peter C. Ellsworth, Steven E. Naranjo, Bruce E. Tabashnik, and Yves Carriere Population Dynamics Models for Assessing the Endocrine Disruption Potential of Juvenile Hormone Analogues on Nontarget Species James Devillers and Hugo Devillers SAR and QSAR Modeling of Juvenile Hormone Mimics James Devillers Using CoMFA and CoMSIA as Tools in a 3D QSAR Analysis of Juvenile Hormone Agonist Action in Drosophila Robert Farkas and Maja Polakovicova Predicting Highly Potent Juvenile Hormone Esterase Inhibitors from 2D QSAR Modeling James Devillers, Annick Doucet-Panaye, and Jean-Pierre Doucet Receptor-Guided Structure-Activity Modeling of Inhibitors of Juvenile Hormone Epoxide Hydrolases Julio Caballero Structural Studies of Juvenile Hormone-Binding Proteins Agnieszka J. Pietrzyk, Mariusz Jaskolski, and Grzegorz Bujacz In Silico Stereoelectronic Profile and Pharmacophore Similarity Analysis of Juvenile Hormone, Juvenile Hormone Mimics (IGRs), and Insect Repellents May Aid Discovery and Design of Novel Arthropod Repellents Apurba K. Bhattacharjee Use of Multicriteria Analysis for Selecting Candidate Insecticides for Vector Control James Devillers, Laurent Lagadic, Ohri Yamada, Frederic Darriet, Robert Delorme, Xavier Deparis, Jean-Philippe Jaeg, Christophe Lagneau, Bruno Lapied, Francoise Quiniou, and Andre Yebakima
James Devillers has authored/edited 13 books and published more than 200 peer-reviewed papers and book chapters in QSAR and (eco)toxicology modeling. He is editor-in-chief of the journal SAR and QSAR in Environmental Research (Taylor & Francis) and editor of the series of books QSAR in Environmental and Health Sciences (CRC Press). James Devillers is also member of the editorial boards of Ecological Modelling (Elsevier), Xenobiotica (Taylor & Francis), and Current Bioactive Compounds (Bentham Science).