Ischemia-reperfusion in cardiac surgery

Name: Ischemia-reperfusion in cardiac surgery
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ISBN: 9789401047500

Hans Michael Piper, C.J. Preusse

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English

Springer
23 October 2012

Cardiovascular medicine; Surgery; Cardiothoracic surgery

Series: Developments in Cardiovascular Medicine

In open heart surgery, protection of the myocardium against

injury by ischemia-reperfusion is an issue of utmost clinical

interest. The knowledge on the causal mechanisms of myocardial injury

in ischemia-reperfusion has greatly progressed in recent years, both

to clinical and experimental research. This book provides a critical

and comprehensive overview on the current discussion of myocardial

protection in cardiac experimental research and surgery. Leading

groups from Europe, the U.S. and Japan have contributed reviews of

their special fields.

On the basic science side, major topics discussed are the mechanisms

of stunning and lethal reperfusion injury, the role of the endothelium

and leukocyte activation in postischemic myocardial dysfunction, and

the differences between the adult and neonatal myocardium. On the

clinical side, the major concepts and procedures for cardioplegic

myocardial protection, their rationales, application and respective

merits are discussed. In a third part of the book, possible approaches

for the monitoring of myocardial injury during ischemia and

reperfusion are evaluated, with particular attention to their

intraoperative use.

This book brings together the scientific discussions on

ischemia-reperfusion in experimental cardiology and cardiac surgery, a

task needed for a long time. It is of general interest for clinicians

as well as research workers and students in the cardiac field.

Edited by: Hans Michael Piper, C.J. Preusse
Imprint: Springer
Edition: Softcover reprint of the original 1st ed. 1993
Volume: 142
Dimensions: Height: 240mm, Width: 160mm, Spine: 24mm
Weight: 754g
ISBN: 9789401047500
ISBN 10: 9401047502
Series: Developments in Cardiovascular Medicine
Pages: 458
Publication Date: 23 October 2012
Audience: Professional and scholarly , Undergraduate
Format: Paperback
Publisher's Status: Active

ONE: Pathophysiology of ischemia and reperfusion.- 1. Moderate ischemic injury and myocardial stunning.- 2. Severe ischemic injury and the oxygen paradox.- 3. Role of leukocytes in reperfusion injury.- 4. Ischemia of the neonatal heart.- TWO: Concepts of cardioplegia.- 5. Cardioplegia with an intracellular formulation.- 6. Cardioplegia with an extracellular formulation.- 7. Blood cardioplegic strategies during adult cardiac operations.- THREE: Clinical application of cardioplegia.- 8. High volume perfusion.- 9. Intermittent coronary perfusion.- 10. Retrograde perfusion.- 11. Cardiac arrest by ventricular fibrillation.- 12. Myocardial preservation in the immature heart.- FOUR: Evaluation of cardioplegic methodology.- 13. High-energy phosphates and their catabolites.- 14. Lactate monitoring during and after cardiopulmonary bypass: an approach implicating a perioperative measure for cardiac energy metabolism.- 15. Myocardial tissue pH in the assessment of the extent of myocardial ischemia and the adequacy of myocardial protection.- 16. Morphology of the acute and chronic ischemic myocardium in man.- 17. Muscle birefringence.- 18. How to measure cardiac energy expenditure.- 19. Cardioplegia and cardiac function.