Inhalation Aerosols

Physical and Biological Basis for Therapy, Third Edition

Anthony J. Hickey (RTI International, North Carolina, USA), Heidi M. Mansour

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English

CRC Press
18 December 2020

Respiratory medicine; Pharmacology; Therapy & therapeutics

Series: Lung Biology in Health and Disease

Inhalation aerosols continue to be the basis for successful lung therapy for several diseases, with therapeutic strategies and the range of technology significantly evolving in recent years.

In response, this third edition takes a new approach to reflect the close integration of technology with its application. After briefly presenting the general considerations that apply to aerosol inhalation, the central section of the book uses the focus on disease and therapeutic agents to illustrate the application of specific technologies.

The final integrated strategies section draws the major points from the applications for disease targets and drug products.

Edited by: Anthony J. Hickey (RTI International North Carolina USA), Heidi M. Mansour
Imprint: CRC Press
Country of Publication: United Kingdom
Edition: 3rd edition
Dimensions: Height: 280mm, Width: 210mm,
Weight: 810g
ISBN: 9780367731489
ISBN 10: 0367731487
Series: Lung Biology in Health and Disease
Pages: 417
Publication Date: 18 December 2020
Audience: Professional and scholarly , Undergraduate
Format: Paperback
Publisher's Status: Active

PART I Fundamentals. 1. Physicochemical Properties of Respiratory Particles and Formulations. 2. Particle Deposition in the Respiratory Tract and the Effect of Respiratory Disease. 3. Mathematical Modeling of Inhaled Therapeutic Aerosol Deposition in the Respiratory Tract. 4. Lung Transporters and Absorption Mechanisms in the Lungs. 5. Bioavailability of Inhaled Compounds. 6. 3D Models as Tools for Inhaled Drug Development. 7. Overview of the Delivery Technologies for Inhalation Aerosols. PART II Applications, Influence of Lung Disease Pathophysiology on Aerosol Deposition, Inhaler Device Technique in Respiratory Disease, and Clinical Outcomes in Drug Performance Assessment. 8. Neonatal and Pediatric Inhalation Drug Delivery. 9. Asthma. 10. Drug Delivery in Pulmonary Aspergillosis. 11. Lung Cancer Inhalation Therapeutics. 12. Inhaled Therapeutics in Chronic Obstructive Pulmonary Disease. 13. Cystic Fibrosis Infection and Biofilm Busters. 14. Current and Future CFTR Therapeutics. 15. Innate and Adaptive Barrier Properties of Airway Mucus. 16. Nontuberculous Mycobacteria. 17. Inhalational Therapies for Non-Cystic Bronchiectasis. 18. Pulmonary Fibrosis. 19. Therapeutics in Pulmonary Hypertension. 20. Overview of Lung Surfactant and Respiratory Distress Syndrome. 21. Surfactant Aerosol Therapy for nRDS and ARDS. 22. Fundamentals in Nasal Drug Delivery. 23. Inhaled therapeutics against TB: The Promise of Pulmonary Treatment and Prevention Strategies in the Clinic. PART III Integrated Strategies (Reflecting Combined Elements from Chapters 8 through 23). 24. Inhaled Medication: Factors That Affect Lung Deposition. 25. A Critical Perspective on Future Developments Based on the Knowledge We Have Now. 26. Ensuring Effectiveness and Reproducibility of Inhaled Drug Treatment. 27. Conclusion.

Hickey, Anthony J. | Mansour, Heidi M.

Reviews for Inhalation Aerosols: Physical and Biological Basis for Therapy, Third Edition

"""This is a comprehensive resource for understanding the fundamentals of inhalation drug development and their use in a variety of lung diseases.This updated edition is likely justified due to the expansion in the technology and development of inhalation drugs in the market."" Santosh Dhungana, MD(Temple University Lewis Katz School of Medicine) ""This is a comprehensive resource for understanding the fundamentals of inhalation drug development and their use in a variety of lung diseases.This updated edition is likely justified due to the expansion in the technology and development of inhalation drugs in the market."" Santosh Dhungana, MD(Temple University Lewis Katz School of Medicine) This book provides a comprehensive review of the aerosol technology literature by separating the text into 3 separate sections. The first section has 7 chapters and evaluates the physiology of aerosol therapy. The second section focuses on the use of aerosol technology in speci!c lung diseases, with 16 chapters focusing on topics including neonatal and pediatric inhalational drug delivery, asthma, chronic obstructive pulmonary disease (COPD), cystic fibrosis, and a chapter exploring nasal drug delivery. The third section is composed of 4 chapters and focuses on integrating strategies, leveraging the information gained from the first 2 sections, exploring such topics as factors affecting lung deposition and future developments in inhalational therapy. This book is extremely well written and referenced with a very logical and concise approach to rich literature, and is a a great resource for clinicians and academicians with an interest in optimizing inhalational therapy. John J. Oppenheimer, MD, FACAAI University of Medicine and Dentistry of New Jersey Newark, New Jersey"