Induction of Bone Formation in Primates

The Transforming Growth Factor-beta 3

Ugo Ripamonti

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Hardback

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English

CRC Press Inc
02 October 2015

Human growth & development; Orthopaedics & fractures; Animal physiology; Primates

The effects of the bone morphogenetic proteins (BMPs) family on bone formation are well documented, but the transforming growth factor (TGF)-beta (β) isoforms are much less studied. The product of 20 years of study, Induction of Bone Formation in Primates: The Transforming Growth Factor-β3 sums up editor Ugo Ripamonti’s research into the osteogenic activity of the three mammalian TGF-β isoforms, particularly in primates. It explores how the mammalian TGF-β isoforms have the potential to shed light on the apparent redundancy of bone induction signaling.

The book unearths the profound and important bone inductive activity of the TGF-β3 isoform. It includes accounts of extensive research in non-human primates from craniofacial tissue regeneration, heterotopic tissue induction, and chapters on periodontal tissue regeneration and synergistic induction of bone formation. It also discusses the future clinical role of the TGF-β isoform, including in human studies.

This book contributes to the fascinating history of BMP and TGF-β research at the intersection of molecular biology, tissue induction, bone regeneration, and craniofacial surgery. It provides a revolutionary awakening to new possibilities in skeletal reconstruction, tissue engineering, and molecular and cellular biology.

Edited by: Ugo Ripamonti
Imprint: CRC Press Inc
Country of Publication: United States
Dimensions: Height: 234mm, Width: 156mm, Spine: 15mm
Weight: 476g
ISBN: 9781482216165
ISBN 10: 1482216167
Pages: 212
Publication Date: 02 October 2015
Audience: General/trade , College/higher education , Professional and scholarly , ELT Advanced , Primary
Format: Hardback
Publisher's Status: Active

Ugo Ripamonti is a leader in the field of tissue induction and differentiation in postnatal osteogenesis. His principal achievement is the demonstration of the induction of bone formation in non-human primate models. In 1994 he was appointed professor at the Medical School University of the Witwatersrand in South Africa, leading its newly founded Bone Research Laboratory. He has written more than 200 publications, given more than 120 invited lectures at international symposia, and organized a series of workshops and symposia at the World Biomaterials Congresses and the International Conferences on Bone Morphogenetic Proteins.