Inflammation, once considered a physiological response to foreign pathogens, is now recognized as a crucial pathological player in the initiation and progression of several chronic diseases, including diabetes, obesity, cancer, Alzheimer’s disease, Parkinson’s disease, and many others. Considering that cardiovascular diseases are a leading cause of death in the United States and worldwide, the identification of critical inflammatory processes is of utmost importance to devising new immune-based therapeutics that can be added to existing regimens. This book provides detailed information on aspects of inflammation and the manner in which immune activation pathways affect the progression of cardiovascular diseases and the repair/regeneration mechanisms of underlying diseased tissues.
Key Features
Outlines the role that inflammation plays in cardiovascular diseases
Describes a paradox – neutralization of cytokines that contribute to cardiovascular disease does not show benefit
Summarizes research on a variety of processes and mechanisms contributing to cardiovascular pathology
Contributions from an international team of leading cardiologists and cardiovascular immunologists
Related Titles
Roy, S., et al., eds. Chronic Inflammation: Molecular Pathophysiology, Nutritional and Therapeutic Interventions (ISBN 978-1-138-19955-2)
Kong, A-N. T., ed. Inflammation, Oxidative Stress, and Cancer: Dietary Approaches for Cancer Prevention (ISBN 978-1-138-19984-2)
Dick, A., et al. Practical Manual of Intraocular Inflammation (ISBN 978-0-367-38720-4)
Edited by:
Shyam S. Bansal
Imprint: CRC Press
Country of Publication: United Kingdom
Dimensions:
Height: 234mm,
Width: 156mm,
Weight: 453g
ISBN: 9780367459079
ISBN 10: 0367459078
Series: Methods in Signal Transduction Series
Pages: 252
Publication Date: 25 April 2022
Audience:
College/higher education
,
Professional and scholarly
,
Primary
,
Undergraduate
Format: Hardback
Publisher's Status: Active
Introduction. Chapter 1. Innate Immune system in Cardiovascular Diseases. Chapter 2. Helper T-cells in Cardiovascular Diseases. Chapter 3. Glucocorticoid Signaling in Heart.Chapter 4. Transforming Growth Factor (TGF)-β/Smad□signaling in myocardial disease. Chapter 5. Fibroblast and Immune Cell crosstalk in Cardiac Repair. Chapter 6. Inflammation, Stem Cell Therapy, and Cardiac Repair. Chapter 7. Cardiovascular Complications of Immune Checkpoint Inhibitors. Chapter 8. Neuronal Regulation of immune system in Cardiovascular Diseases. Chapter 9. Immune Responses Regulated by Exosomal Mechanisms in Cardiovascular Disease. Chapter 10. Ion Channels in Immune Cells: Physiological and Pathophysiological Roles.
Shyam S. Bansal is a a cardiovascular immunologist with expertise in the immune-inflammatory pathways of myocardial infraction and heart failure. His research endeavors focus on the elucidation of innate (macrophages and dendritic cell) and adaptive (T-cells) immune responses during chronic heart failure and the role of these immune cells in mediating pathological left-ventricular remodeling. He is particularly interested in deciphering the role of T-cell subsets and time-dependent phenotypic changes that these cells undergo during chronic HF. He is also interested in identifying and developing novel therapeutic strategies to reverse pathological changes in the immune cells for their bench-to-bed transition. Shyam S. Bansal is an Assistant professor in the Department of Physiology and Cell Biology at the Ohio State University. He received a PhD from the Department of Pharmacology & Toxicology at the University of Louisville, Louisville, KY in 2011. Bansal's first post-doctoral training was in the Department of Nanotechnology at the Methodist Hospital Research Institute (09/2011-09/2012) followed by an extensive post-doctoral training (from 09/2012-07/2018) in studying the role of helper T-cells and Regulatory T cells in mediating pathological left-ventricular remodeling and ischemic heart failure.
Reviews for Immune Cells, Inflammation, and Cardiovascular Diseases
'This is the 10th book of the Methods in Signal Transduction Series, which covers the role of immune cells and inflammatory pathways in relation to cardiovascular diseases. With over 30 authors, the book presents all aspects of the subject matter in a concise package. Researchers in the field of cardiology will find this collection a valuable reference.' - Massoud Mahmoudi, DO, PhD, University of California San Francisco
