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English
Academic Press Inc
19 June 2020
Human pluripotent stem cell derived organoid models
Volume editor:  
Imprint:   Academic Press Inc
Country of Publication:   United States
Dimensions:   Height: 235mm,  Width: 191mm, 
Weight:   860g
ISBN:   9780128215319
ISBN 10:   0128215313
Series:   Methods in Cell Biology
Pages:   336
Publication Date:  
Audience:   Professional and scholarly ,  Undergraduate
Format:   Hardback
Publisher's Status:   Active

Jason R. Spence, PhD, is an Associate Professor of Internal Medicine, Cell and Developmental Biology and Biomedical Engineering at the University of Michigan Medical School. He attended Canisius College in Buffalo, NY, as an undergraduate. He attended graduate school at Miami University (Ohio) where his research focused on understanding mechanisms that drive regeneration and tissue repair in unique model organisms that maintain regenerative ability throughout life, including Notophthalmus viridescens (Eastern Newt), Ambystoma mexicanum (Axolotl) and the chick. He performed postdoctoral research Cincinnati Children’s Hospital, where he turned his focus to understanding mechanisms that regulate embryonic development of endoderm-derived tissue (pancreas, liver, intestine) and utilized human pluripotent stem cells (hPSCs) to understand human differentiation and development. During this time, he pioneered methods to differentiate 3-dimensional intestinal organoids from human pluripotent stem cells. In 2011, Dr. Spence joined the faculty of the University of Michigan Medical School. The focus of the Spence lab include using 3-dimensional organoid human models to study human development and disease, with research focused on understanding intestinal, lung and esophageal development, homeostasis and disease.

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