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How the Immune System Works
— —
Lauren M. Sompayrac
How the Immune System Works by Lauren M. Sompayrac at Abbey's Bookshop,

How the Immune System Works

Lauren M. Sompayrac



Medical study & revision guides


168 pages

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How the Immune System Works has helped thousands of students understand what's in their hefty immunology textbooks. In this book, Dr. Sompayrac cuts through the jargon and details to reveal, in simple language, the essence of this complex subject: how the immune system fits together, how it protects us from disease and, perhaps most importantly, why it works the way it does.

Featuring Dr. Sompayrac's hallmark lively prose and engaging analogies, How the Immune System Works has been rigorously updated for this sixth edition, including the latest information on subjects such as vaccines, immunological memory, and cancer. A highlight of this edition is a new chapter on immunotherapies - currently one of the hottest topics in immunology.

Whether you are completely new to immunology, or require a refresher, How the Immune System Works will provide you with a clear and engaging overview of this fascinating subject.

By:   Lauren M. Sompayrac
Imprint:   Wiley-Blackwell
Country of Publication:   United States
Edition:   6th Edition
Dimensions:   Height: 276mm,  Width: 216mm,  Spine: 9mm
Weight:   496g
ISBN:   9781119542124
ISBN 10:   111954212X
Series:   The How it Works Series
Pages:   168
Publication Date:   April 2019
Audience:   Professional and scholarly ,  Undergraduate
Format:   Paperback
Publisher's Status:   Active

Acknowledgments viii How to Use This Book ix This book is neither a comprehensive text nor an exam-review tool. It is an overview of the immune system designed to give anyone who is learning immunology a feel for how the system fits together. About the Companion Website x Lecture 1 An Overview 1 The immune system is a team effort involving many different players who work together to provide a powerful defense against invaders. Focusing on one player at a time makes it hard to understand the game. Here we view the action from the grandstands to get a wide-angle picture of what the immune system is all about. Lecture 2 The Innate Immune System 13 The innate immune system is a hard-wired defense that has evolved over millions of years to recognize pathogens that commonly infect humans. It provides a rapid and powerful response against everyday invaders. Lecture 3 B Cells and Antibodies 27 B cells and the antibodies they produce are part of the adaptive immune system - a system that protects us against pathogens both common and rare. Lecture 4 The Magic of Antigen Presentation 42 T cells another weapon of the adaptive immune system only recognize invaders which are properly presented by specialized antigen presenting cells. This feature keeps T cells focused on the types of attackers they can defend against. Lecture 5 T Cell Activation 55 Before they can spring into action T cells must be activated. This requirement helps insure that only useful weapons will be mobilized. Lecture 6 T Cells at Work 62 Once they have been activated helper T cells orchestrate the immune response and killer T cells destroy infected cells. Lecture 7 Secondary Lymphoid Organs and Lymphocyte Trafficking 71 B and T lymphocytes travel through secondary lymphoid organs looking for the intruders they can defend against. Once activated in the secondary lymphoid organs B and T cells are dispatched to the particular areas of the body where they can be most useful. Lecture 8 Restraining the Immune System 83 The powerful weapons of the immune system must be restrained lest they become over-exuberant. In addition once an invader has been defeated the immune system must be reset to prepare for future attacks. Lecture 9 Self Tolerance and MHC Restriction 87 T cells must be tested to be sure they focus on appropriately presented antigens and B and T lymphocytes must be screened to eliminate those which might attack our own bodies. Lecture 10 Immunological Memory 98 The innate immune system remembers pathogens which have been attacking humans for millions of years. In contrast B and T cells remember pathogens we have encountered during our lifetime. Memory B and T lymphocytes respond more quickly and effectively to a subsequent attack by the same invader. Lecture 11 The Intestinal Immune System 104 The human intestines are home to trillions of bacteria viruses fungi and parasites. How the immune system deals with these potentially dangerous intestinal residents which frequently invade the tissues surrounding the intestines is a hot topic in immunology. Lecture 12 The Immune System Gone Wrong 111 The immune system usually does a good job of defending us. Sometimes however mistakes are made. Two examples of the immune system gone wrong are allergies and autoimmunity. Lecture 13 Immunodeficiency 120 Serious disease may result when our immune system does not operate at full strength. Humans who are infected with the AIDS virus have profoundly impaired immune systems. Lecture 14 Vaccines 125 Vaccines safely mimic a microbial attack so that our immune system will be primed and ready for a future challenge by the same pathogen. Lecture 15 Cancer and the Immune System 132 The human immune system is not very good at defending us against cancer. Indeed there is a built-in conflict between the need to minimize the chance that its weapons will attack our own bodies and the need to destroy cancer cells. Lecture 16 Immunotherapy 139 Although the immune system evolved to keep invaders from infecting us physicians are borrowing some of the weapons of the immune system and using them to treat disease. Glossary 146 Here are definitions of some of the terms that immunologists use - but which normal people wouldn't. List of Acronyms and Abbreviations 150 Immunologists are big on acronyms and abbreviations but they can drive you crazy. So I've made a list to which you can refer. Index 151

LAUREN SOMPAYRAC, Retired Professor, University of Colorado, Boulder, USA

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