The CAPRISA Clinical Trials

HIV Treatment and Prevention

Quarraisha Abdool Karim, Salim S. Abdool Karim, Cheryl Baxter

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QTY:

English

Springer International Publishing AG
26 January 2017

Clinical trials; Public health & preventive medicine; HIV & AIDS

Since its inception 14 years ago, CAPRISA has conducted numerous clinical studies that have influenced international TB-HIV treatment guidelines as well as HIV prevention through innovations in the microbicide and vaccine fields. This book provides a historical account of how each of CAPRISA’s high impact studies was created, developed, implemented, analysed and communicated. In doing so, the reader is taken on a journey that provides glimpses into the genesis of research ideas and how this ultimately leads to a range of HIV prevention and treatment studies that have impacted the global response to the HIV and TB epidemics.

Comprised of 5 sections, the book details the following:

HIV epidemic in

South Africa and the establishment of a research centre to undertake

clinical, epidemiological and laboratory research on HIV. CAPRISA’s clinical trials on HIV and HSV-2 prevention. These studies

investigated the impact of tenofovir gel as topical antiretroviral

pre-exposure prophylaxis (PrEP), implementation of topical PrEP through

family planning clinics, conditional cash incentives for HIV prevention,

HIV vaccines, and passive immunisation with broadly neutralising antibodies.

CAPRISA’s research on the treatment of HIV and TB co-infection.

A review

of the major scientific findings from the CAPRISA studies on acute infection

and genital mucosal immunology.

Essential

support activities for the conduct of clinical trials, including research laboratories and pharmacies, as well as

establishing effective communication and sustainable structures for

community engagement to maintain effective and respectful partnerships

with participating communities. The book concludes with a chapter about the

challenges facing future HIV prevention and treatment trials.

The CAPRISA ClinicalTrials: HIV Treatment and Prevention is a resource for undergraduate and postgraduate students, health care providers, doctors, decision-makers and researchers who are seeking guidance and insights on clinical trials – their creation, conduct and impact.

Edited by: Quarraisha Abdool Karim, Salim S. Abdool Karim, Cheryl Baxter
Imprint: Springer International Publishing AG
Country of Publication: Switzerland
Edition: 1st ed. 2017
Dimensions: Height: 235mm, Width: 155mm, Spine: 16mm
Weight: 5.029kg
ISBN: 9783319475172
ISBN 10: 3319475177
Pages: 243
Publication Date: 26 January 2017
Audience: Professional and scholarly , Undergraduate
Format: Hardback
Publisher's Status: Active

Part I. Introduction.- Studies Linked to the Evolving HIV Epidemic in South Africa: Informing the CAPRISA Scientific Agenda.- CAPRISA: Establishing A Research Center to Undertake HIV Clinical Trials.- Overview of Clinical Trials.- Part II. CAPRISA Clinical Trials for HIV and HSV-2 Prevention.- Antiretrovirals for HIV Prevention.- Rolling out of tenofovir gel in family planning clinics: the CAPRISA 008 implementation trial.- Conditional cash transfers to reduce HIV risk in young women: the CAPRISA 007 cluster randomised control trial.- HIV vaccine and passive immunity trials.- Part III: CAPRISA Clinical Trials for HIV–TB Treatment.- CAPRISA 003: Timing of antiretroviral initiation in HIV-TB co-infected patients - The SAPiT Trial.- Scaling up TB-HIV integration in public health clinics: translating research findings into practice.- Part IV: Experiences and lessons learnt from clinical trials in CAPRISA.- Lessons from the Acute Infection Study: from Bench to Bedside.- Understanding sexual HIV transmission in women by focusing on the genital mucosa.- Part V: Essential support activities for the conduct of clinical trials.- Good practices in conducting clinical trials: Good Participatory Practice, Good Pharmacy Practice and Good Laboratory Practice.- Grants Management.- Taking science to the people: communication and media strategies for clinical trials.- Looking ahead: What Does the Future Hold for CAPRISA?.- Appendix.- Index.

Quarraisha Abdool Karim, Centre for the AIDS Programme of Research in South Africa (CAPRISA); Department of Epidemiology, Columbia University, New York, USA Salim S. Abdool Karim, Centre for the AIDS Programme of Research in South Africa (CAPRISA); Department of Epidemiology, Columbia University, New York, USA Cheryl Baxter, Centre for the AIDS Programme of Research in South Africa (CAPRISA)