Histophysiology of the Obesity-Diabetes Syndrome in Sand Rats

Herwig Hahn von Dorsche, Harald Schäfer, Milan Titlbach

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English

Springer-Verlag Berlin and Heidelberg GmbH & Co. K
15 June 1994

Medical research; Diabetes; Veterinary medicine: laboratory animals

Series: Advances in Anatomy, Embryology and Cell Biology

The book gives a review of the state-of-the-art of recent investigations of the adipositas diabetes syndrome of sand rats kept under laboratory conditions and given various diet regimes. Measurements of specific activities and flux rates in carbohydrate and fat metabolism determined by different analytical methods in vitro and in vivo provide insights into the pathophysiology and pathobiochemistry of different forms of the diabetic syndrome which cannot be obtained in humans.

By: Herwig Hahn von Dorsche, Harald Schäfer, Milan Titlbach
Imprint: Springer-Verlag Berlin and Heidelberg GmbH & Co. K
Country of Publication: Germany
Volume: 130
Dimensions: Height: 235mm, Width: 155mm, Spine: 5mm
Weight: 215g
ISBN: 9783540579137
ISBN 10: 3540579133
Series: Advances in Anatomy, Embryology and Cell Biology
Pages: 95
Publication Date: 15 June 1994
Audience: College/higher education , Professional and scholarly , Further / Higher Education , Undergraduate
Format: Paperback
Publisher's Status: Active

1 Introduction.- 1.1 Experimental Diabetes in the Sand Rat.- 2 Aims of the Study.- 2.1 Islet Cytology.- 2.2 Islets of Langerhans and Other Endocrine Organs in Diabetes Mellitus.- 3 Materials and Methods.- 3.1 Animal Housing.- 3.2 Animal Preparation and Investigation.- 3.3 Histological Methods.- 3.4 Cytochemical Methods.- 3.5 Electron Microscopy.- 3.6 Morphometry.- 4 Islets.- 4.1 Islet Cytology.- 4.2 Innervation of the Pancreas and Islets of Langerhans.- 4.3 Islets of Langerhans in Diabetes Mellitus.- 4.4 Insulin Secretion of Islets of Langerhans.- 4.5 Insulin Resistance of Insulin-Sensitive Tissues.- 4.6 Influence of Stress on Insulin Resistance of Glucose Utilization and Hyperinsulinemia.- 5 Role of Other Endocrine Organs in Diabetes Mellitus.- 5.1 Adenohypophysis.- 5.2 Adrenal Cortex.- 5.3 Thyroid.- 5.4 Testicles.- 5.5 Ovaries.- 6 Conclusions.- 7 Summary.- References.