Hereditary Breast Cancer

Claudine Isaacs, Timothy R. Rebbeck

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English

CRC Press
19 June 2019

Oncology; Gynaecology & obstetrics; Surgical oncology

Intended for medical oncologists, surgeons, obstetricians, gynecologists, geneticists, genetic counselors, and primary care physicians, this text presents the epidemiological, biological, and clinical issues associated with hereditary breast cancer. It offers clear guidance on the application and utilization of cancer risk assessment models, genetic counseling and testing of high risk patients, and screening and prevention options for individuals at risk of hereditary breast cancer. Addressing every essential aspect of hereditary breast cancer, this source offers comprehensive analyses of hereditary breast cancer-associated syndromes, low penetrance genes, and hereditary breast cancer associated with mutations in the BRCA1 and BRCA2 genes.

Edited by: Claudine Isaacs, Timothy R. Rebbeck
Imprint: CRC Press
Country of Publication: United Kingdom
Dimensions: Height: 254mm, Width: 178mm,
Weight: 453g
ISBN: 9780367388621
ISBN 10: 0367388626
Pages: 400
Publication Date: 19 June 2019
Audience: College/higher education , Professional and scholarly , Primary , Undergraduate
Format: Paperback
Publisher's Status: Active

Introduction. OVERVIEW OF HEREDITARY BREAST CANCER. Genetic Epidemiology of Hereditary Breast Cancer. Breast Cancer Risk Estimation Models. Bioethics of Genetic Testing for Hereditary Breast Cancer. HBC SYNDROMES WITH KNOWN GENETIC ETIOLOGIES. Cancer Risks in BRCA1 and BRCA2 Mutation Carriers. Cowden's Syndrome. Li-Fraumeni Syndrome. Other Syndromes that Include Breast Cancer as a Component. Low penetrance genes. ASSESSMENT AND DISSEMINATION OF CLINICAL RISKS FOR BRCA1/2 MUTATION CARRIERS. Biology of BRCA1/2-associated Carcinogenesis. Genetic Testing and Counseling Issues. Molecular Diagnostics: Methods and Limitations. Cancer Risk Modifiers. BRCA1/2 in underserved or special populations. Psychological Impact of Genetic Testing. SCREENING AND PREVENTION OF HBC. Breast Cancer Screening and Prevention Options. Ovarian Cancer Screening and Prevention Options. Management of mutation-negative women. CLINICAL MANAGEMENT OF HBC. Pathology of Breast Tumors in Hereditary Breast Cancer. Pathology of Ovarian Tumors in Mutation Carriers. Local treatment Issues in HBC. Breast Cancer in Mutation Carriers.Impact on Systemic Therapy.

Claudine Isaacs, Timothy R. Rebbeck