Handbook of Tissue Optical Clearing: New Prospects in Optical Imaging

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Valery V. Tuchin Dan Zhu (Huazhong University of Science and Technology, Hubei, China)

Handbook of Tissue Optical Clearing

New Prospects in Optical Imaging

Valery V. Tuchin, Dan Zhu (Huazhong University of Science and Technology, Hubei, China), Elina A. Genina

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English

CRC Press
27 May 2024

Neurology & clinical neurophysiology; Neurosciences

Biomedical photonics is currently one of the fastest growing fields, connecting research in physics, optics, and electrical engineering coupled with medical and biological applications. It allows for the structural and functional analysis of tissues and cells with resolution and contrast unattainable by any other methods.

However, the major challenges of many biophotonics techniques are associated with the need to enhance imaging resolution even further to the sub-cellular level as well as translate them for in vivo studies. The tissue optical clearing method uses immersion of tissues into optical clearing agents (OCAs) that reduces the scattering of tissue and makes tissue more transparent and this method has been successfully used ever since.

This book is a self-contained introduction to tissue optical clearing, including the basic principles and in vitro biological applications, from in vitro to in vivo tissue optical clearing methods, and combination of tissue optical clearing and various optical imaging for diagnosis. The chapters cover a wide range of issues related to the field of tissue optical clearing: mechanisms of tissue optical clearing in vitro and in vivo; traditional and innovative optical clearing agents; recent achievements in optical clearing of different tissues (including pathological tissues) and blood for optical imaging diagnosis and therapy.

This book provides a comprehensive account of the latest research and possibilities of utilising optical clearing as an instrument for improving the diagnostic effectiveness of modern optical diagnostic methods.

The book is addressed to biophysicist researchers, graduate students and postdocs of biomedical specialties, as well as biomedical engineers and physicians interested in the development and application of optical methods in medicine.

Key features:

The first collective reference to collate all known knowledge on this topic

Edited by experts in the field with chapter contributions from subject area specialists

Brings together the two main approaches in immersion optical clearing into one cohesive book

Edited by: Valery V. Tuchin, Dan Zhu (Huazhong University of Science and Technology, Hubei, China), Elina A. Genina
Imprint: CRC Press
Country of Publication: United Kingdom
Dimensions: Height: 280mm, Width: 210mm,
ISBN: 9781032118697
ISBN 10: 1032118695
Pages: 658
Publication Date: 27 May 2024
Audience: College/higher education , Professional and scholarly , Primary , Undergraduate
Format: Paperback
Publisher's Status: Forthcoming

Valery V. Tuchin, Dan Zhu, Elina A. Genina

Reviews for Handbook of Tissue Optical Clearing: New Prospects in Optical Imaging

The book—subtitled “New Prospects in Optical Imaging”—is unique in bringing together a number of diverse tissue optical clearing (TOC) topics, such as 3D imaging and the combination of TOC and optical imaging/spectroscopy for diagnostics, and presenting it all at a level suitable for graduate students in biophysics and engineering. This task is accomplished with an emphasis on both methodology and applications. I found the description of these basic biophotonics techniques particularly detailed and interesting. Although written by more than 100 contributors, the style of the book is generally clear and fluent. Review by Christian Brosseau, Optica Fellow and professor of physics, Université de Bretagne Occidentale, Brest, France, June 2022.