Emerging imaging techniques have opened new fronts to investigate tissues, cells, and proteins. Transformative technologies such as microCT scans, super-resolution microscopy, fluorescence-based tools, and other methods now allow us to study the mechanics of cancer, dissect the origins of cellular force regulation, and examine biological specimens at the nanoscale.
The Handbook of Imaging in Biological Mechanics presents the spectrum of imaging techniques used for noninvasive visualization of the morphology and mechanics of the large and small-from organs to individual macromolecules.
The handbook presents optimal imaging technologies to study deformation, stress, and constitutive behavior of tissues, cells, and proteins. It also describes a suite of technologies available for probing the mechanics of surfaces, membranes, and single molecules. With chapters authored by highly recognized experts in their area, the handbook covers the entire spectrum of biomechanical and mechanobiologic imaging technologies available today.
Corey P. Neu
, Guy M. Genin
CRC Press Inc
Country of Publication:
24 October 2014
Professional and scholarly
Mixed media product
INTRODUCTION Imaging in Biological Mechanics; Corey P. Neu and Guy M. Genin TISSUE AND ORGAN IMAGING METHODS: MAGNETIC RESONANCE IMAGING METHODS MRI Tagging of the Heart; Leon Axel and Solae Chung Frequency-Domain Analysis of Tagged MRI and Imaging Strategies; Khaled Z. Abd-Elmoniem, Vijay Parthasarathy, and Jerry L. Prince Magnetic Resonance Elastography; Jiming Zhang and Raja Muthupillai Magnetic Resonance Elastography of the Brain; Philip V. Bayly, Erik H. Clayton, Guy M. Genin, and Ruth J. Okamoto Displacements under Applied Loading by MRI in Soft Biomaterials and Tissues; Corey P. Neu TISSUE AND ORGAN IMAGING METHODS: ULTRASOUND Ultrasound and Optical Methods for Dynamic Viscoelastic Imaging; Yue Wang, Steven G. Adie, Stephen A. Boppart, and Michael F. Insana Ultrasound Imaging of Mechanical Properties of Cancers; Brian S. Garra TISSUE AND ORGAN IMAGING METHODS: RADIOGRAPHY AND COMPUTED TOMOGRAPHY Computed Tomography Image-Based Kinematic Analysis: An Overview; Douglas C. Moore, Eni Halilaj, Tarpit K. Patel, and Joseph J. Crisco III Contrast-Enhanced MicroCT Imaging; David Reece, Angela Lin, and Robert E. Guldberg TISSUE AND ORGAN IMAGING METHODS: HIGH THROUGHPUT AND IMAGE QUANTIFICATION Application of Digital Image Correlation for Multiscale Biomechanics; Hui Wang, William Lai, Antonia Antoniou, and Ashraf Bastawros Image-Based Estimation of Passive Myocardial Properties Using Finite Element Modeling; Alexander I. Veress, Benjamin R. Coleman, Genevieve Farrar, W. Paul Segars, and Brian C. Fabien Particle Image Velocimetry for Biological Mechanics; Zachary J. Taylor, Roi Gurka, and Alex Liberzon High-Throughput Imaging Methodologies for Biomechanical Testing; Yu Long Han, Guoyou Huang, Lin Wang, Xiaoxi Fan, Fei Li, Pengfei Wang, Tian Jian Lu, and Feng Xu TISSUE AND ORGAN IMAGING METHODS: MULTISCALE IMAGING AND MODELING Nonlinear and Poroelastic Biomechanical Imaging: Elastography Beyond Young's Modulus; Paul E. Barbone, Assad A. Oberai, Jeffrey C. Bamber, Gearoid P. Berry, Jean-Francois Dord, Elizabete Rodrigues Ferreira, Sevan Goenezen, and Timothy J. Hall Quantitative Anatomy Using Design-Based Stereology; Peter R. Mouton Brain Shift Compensation via Intraoperative Imaging and Data Assimilation; Songbai Ji, Xiaoyao Fan, David W. Roberts, Alex Hartov, Timothy J. Schaewe, David A. Simon, and Keith D. Paulsen Noninvasive Determination of Material Properties for Biological Materials; Kent Butz, Deva Chan, Corey P. Neu, and Eric A. Nauman CELLULAR AND MOLECULAR IMAGING METHODS: MICROENVIRONMENTS: NATIVE ECM Nonlinear Optical Microscopy in Biomechanics; Jessica C. Mansfield, James S. Bell, Julian Moger, and C. Peter Winlove Collagen-Cell Interactions in Three-Dimensional Microenvironments; Sherry L. Voytik-Harbin and Bumsoo Han Integrated Modeling and Imaging for Quantifying the Mechanics of Cells in Three-Dimensional Culture; Guy M. Genin and Elliot L. Elson CELLULAR AND MOLECULAR IMAGING METHODS: MICROENVIRONMENTS: IN VITRO CULTURE SYSTEMS Measurement of Cellular Forces via Traction Force Microscopy; Wesley R. Legant Cell Interactions in Wire (Fiber)-Based Structures and Scaffolds; Kevin Sheets, Puja Sharma, Brian Koons, and Amrinder Nain Mechanical Stretch Assays in Cell Culture Systems; Abhishek Tondon, Candice Haase, and Roland Kaunas CELLULAR AND MOLECULAR IMAGING METHODS: CELLULAR AND SUBCELLULAR BIOPHYSICS Micropipette Aspiration and Subcellular Biophysics; Baoyu Liu and Jin-Yu Shao Scanning Probe Investigation of Cellular and Subcellular Biomechanics; Sirimuvva Tadepalli, Keng-Ku Liu, and Srikanth Singamaneni Fluorescence-Based Tools for Quantifying Adhesion Dynamics; Haguy Wolfenson Nanoscale Mechanical Testing of FIB-Isolated Biological Specimens; Ines Jimenez-Palomar, Russell J. Bailey, and Asa H. Barber Imaging Cellular Mechanotransduction Using FRET-Based Biosensors; Qiaoqiao Wan, Yu-Hui Lai, and Sungsoo Na Intracellular Particle Tracking Microrheology; Michelle R. Dawson, Yiider Tseng, Jerry S.H. Lee, and Kathleen M. McAndrews CELLULAR AND MOLECULAR IMAGING METHODS: NUCLEAR BIOPHYSICS Probing Chromatin Structure and Dynamics Using Fluorescence Anisotropy Imaging; Ekta Makhija, K. Venkatesan Iyer, Shefali Talwar, and G.V. Shivashankar Nuclear Imaging in Mechanobiology; Irena L. Ivanovska, Joe Swift, Jerome Irianto, Kyle Spinler, Jae-Won Shin, Amnon Buxboim, and Dennis E. Discher Intranuclear Measurement of Deformation in Single Cells; Jonathan T. Henderson and Corey P. Neu CELLULAR AND MOLECULAR IMAGING METHODS: CHANNELS Fluorescence Methods for Monitoring Mechanosensitive Channels; Alexander Macmillan, Charles G. Cranfield, and Boris Martinac Channel Activation and Mechanotransduction; Henry J. Donahue, Randall L. Duncan, and Damian C. Genetos CELLULAR AND MOLECULAR IMAGING METHODS: SURFACES AND SINGLE MOLECULE MEASUREMENTS Characterization of Intermolecular and Intramolecular Interactions with the Atomic Force Microscope; Gil U. Lee, Krasimir Ivanov, Devrim Kilinc, Elena Martines, Agata Blasiak, Peng Li, and Michael J. Higgins Characterization of Biomolecular Interactions with the Surface Forces Apparatus; Marina Ruths, Carlos Drummond, and Jacob N. Israelachvili Magnetic Tweezers Force Spectroscopy; Eric A. Galburt Analytical Electron Microscopy of Bone and Mineralized Tissue; Michal Klosowski, Alexandra E. Porter, Sandra J. Shefelbine, and David W. McComb Optical Microscopy Methods for Measuring Structure and Dynamic Processes of Cells and Tissues; Elliot L. Elson FABLE and Image Processing; Ali Nekouzadeh and Niloufar Ghoreishi
Corey Neu directs the Soft Tissue Bioengineering Laboratory at Purdue University and holds an appointment on the faculty in Purdue's Weldon School of Biomedical Engineering. He earned a PhD in biomedical engineering from the University of California, Davis. Dr. Neu studies force transfer in cells and tissues in the context of disease and regeneration. His current research focuses on structural and mechanical changes to articular cartilage in the pathogenesis of osteoarthritis, and multiscale biomechanics and mechanobiology of collagen-rich tissues. Guy Genin holds appointments on the faculty of the Department of Mechanical Engineering and Materials Science at Washington University in St. Louis, and the Department of Neurosurgery at the Washington University School of Medicine. Dr. Genin earned his PhD in applied and solid mechanics from Harvard University. He studies interfaces and adhesion in nature, physiology, and engineering. He is the recipient of numerous awards for engineering design, teaching, and research, including a Research Career Award from the National Institutes of Health and the Skalak Award from the American Society of Mechanical Engineers.