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English
Academic Press Inc
23 November 2022
Handbook of Animal Models in Neurological Disorders will better readers' understanding of a large variety of animal models and their applicability in studying a number of neurological disorders. Featuring sections on brain injury, stroke and neuroinflammation, this volume discusses in detail the utility, success and pitfalls of multiple models for each condition. Multiple disorders are covered, ranging from neurodegenerative diseases like Alzheimer's, Parkinson's, and ALS, to multiple sclerosis, headache, migraine, and others. With expert authors, this book has applicability for anyone pursuing neuroscience or biomedical research working to better understand, study and ultimately treat neurological dysfunction.

Edited by:   , , , , , , , , ,
Imprint:   Academic Press Inc
Country of Publication:   United Kingdom
Dimensions:   Height: 276mm,  Width: 216mm, 
ISBN:   9780323898331
ISBN 10:   0323898335
Pages:   700
Publication Date:  
Audience:   Professional and scholarly ,  Undergraduate
Format:   Hardback
Publisher's Status:   Active
Section 1: Alzheimer's Disease and Dementias 1. Caenorhabditis elegans model of Alzheimer's disease: applications to drug screening 2. APPswe/ PS1dE9 mouse model of Alzheimer's disease: [18F]-florbetaben pet/ct imaging and beyond 3. Rat model of Alzheimer: applications to brain a-beta plaque accumulation Section 2: Amyotrophic Lateral Sclerosis 4. Murine modelling of familial amyotrophic lateral sclerosis, SOD1G86R: applications to ambroxol HCl 5. Rat Model of amyotrophic lateral sclerosis: SOD1G93A applications to mitochondria 6. Zebrafish model of amyotrophic lateral sclerosis: applications to oxidative stress studies in spinal motor neurons Section 3: Brain Injury 7. Murine models of traumatic brain injury and knock outs: investigations on hypocretin 8. Rat model of cortical impact traumatic brain injury: applications to studying neural stem cell grafts 9. Porcine modelling of traumatic brain injury: investigating agents such as valproic acid and beyond Section 4: Cerebral Palsy 10. Animal models of cerebral palsy: a new narrative 11. Rat model of cerebral palsy: applications to studying motor phenotype 12. Rabbit cerebral palsy modelling: applications to studying spinal hyper-excitability Section 5: Epilepsy 13. Murine modelling of epilepsy: applications to microRNA and hippocampus 14. Kainic acid-induced rat model of status epilepticus: A gamma-aminobutyric acid levels 15. Rats modelling of temporal lobe epilepsy: linking in cognition Section 6: Headaches and Migraines 16. A new narrative of genetic mouse models of migraine: features and applications 17. Rat model of headache with nitroglycerin: impact of auricular electrical stimulation 18. Nitroglycerin-induced migraine in mice: Nociceptin Opioid (NOP) receptors and beyond Section 7: Meningitis Rabbit tuberculous meningitis models: applications to neurosciences 19. Experimental pneumococcal meningitis: hippocampal DNA methylation 20. Pneumococcal meningitis modelling in mice Section 8: Multiple Sclerosis Biological models in multiple sclerosis: a new overview and narrative 21. The mouse model of multiple sclerosis : use of Artemisia dracunculus L. 22. Comparing models of multiple sclerosis: applications to biomarkers Section 9: Neuroinflammation Modelling neuroinflammation: CXCR2 signalling and myelin repair 23. Lipopolysaccharide- model of neuroinflammation: astrogliosis, microglial activation and beyond 24. Rat model of neuroinflammation: positron emission tomography (PET) tracer for imaging of P2X7 receptors Section 10: Neurotoxins Animal models in the neurotoxicology of the neurotoxin 2,4-D 25. Toluene as a model neurotoxin in mouse models 1-11-2019 26. Rat model of alcohol-related brain damage: application to thiamine deficiency and cytokines Section 11: Parkinson's Disease 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine( MPTP)-induced mouse model of Parkinson's disease: impact of Valeriana officinalis 27. alpha-synuclein BAC transgenic mice model of Parkinson's disease: the sublaterodorsal tegmental nucleus and beyond 28. Rat model of parkinsonism: the nigro-vagal pathway Section 12: Peripheral Neuropathy Non-mammalian animal models of peripheral neuropathy 29. Mouse models of peripheral neuropathy: neurogenic molecule NSI-189 30. Rat model of cisplatin-induced peripheral neuropathy: features and applications Section 13: Prenatal Related Injury Porcine model of intrauterine growth restriction: Applications to the study of the hippocampus 31. Ethanol as a neurotoxin in model primates for in vitro exposure: brain development and beyond 32. Prenatal malnutrition: linking in oxidative stress Section 14: Stroke Mouse model of ischemic stroke: PET tracers 33. Canine model of stroke: optimizing complex multimodal treatment 34. Porcine Ischemic Stroke and applications to neural stem cells

Dr. Martin is a Professor of Mental Health at Buckinghamshire New University. He is a Registered Nurse, Chartered Health Psychologist, and a Chartered Scientist. He has published or has in press well over 250 research papers and book chapters. He is a keen book author and editor having written and/or edited several books all of which reflect his diverse academic and clinical interests that examine in-depth, the interface between mental health and physical health. These outputs include the Handbook of Behavior; Food and Nutrition (2011), Perinatal Mental Health: A Clinical Guide (2012); Nanomedicine and the Nervous System (2012), and the major reference works Comprehensive Guide to Autism (2014), Diet and Nutrition in Dementia and Cognitive Decline (2015), Comprehensive Guide to Post-Traumatic Stress Disorder (2016) and Metabolism and Pathophysiology of Bariatric Surgery: Nutrition, Procedures, Outcomes, and Adverse Effects (2017). Dr. Patel is a Reader at the University of Westminster. After completing his PhD at King's College London, he continued his research experience by undertaking his post-doctoral studies in the laboratory of Professor Cunningham in the Department of Biochemistry at the Wake Forest University School of Medicine, (Winston-Salem, NC, USA). This extensive project involved investigating mechanisms of hepatic mitochondrial ribosome dysfunction in alcoholic liver disease (ALD) using biophysical and proteomic techniques. These studies have led to new avenues in determining the pathology of ALD. His teaching areas at both post-graduate and undergraduate levels include clinical biochemistry, investigative pathology and laboratory investigation. Victor R. Preedy BSc, PhD, DSc, FRSB, FRSPH, FRCPath, FRSC is Emeritus Professor of Nutritional Biochemistry, at King's College London and Professor of Clinical Biochemistry (Hon) at King's College Hospital. He was the long-term Director of the Genomics Centre at King's College London from 2006 to 2020. Professor Preedy has carried out research when attached to Imperial College London, The School of Pharmacy (now part of University College London) and the MRC Centre at Northwick Park Hospital. He has collaborated with research groups in Finland, Japan, Australia, USA and Germany. Prof. Preedy is a leading expert on the science of health and has a long-standing interest in dietary and plant-based components. To his credit, Professor Preedy has published over 750 articles, which includes peer-reviewed manuscripts based on original research, abstracts and symposium presentations, reviews and numerous books and volumes.

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