Gold(I,III) Complexes Designed for Selective Targeting and Inhibition of Zinc Finger Proteins

— —

Raphael Enoque Ferraz de Paiva

Gold

I,III Complexes Designed for Selective Targeting and Inhibition of Zinc Finger Proteins

Raphael Enoque Ferraz de Paiva

$251.95 $201.58

Hardback

Not in-store but you can order this
How long will it take?

Availability Information

We source books from suppliers in Australia and overseas. For books we don't currently have in stock, the time it takes to get them from our suppliers can vary widely - from a few days to a few months - so we check each book with each supplier to determine the expected time it will take to be supplied to us.

We then advise you accordingly. If the time taken to get any book is too long for you, you can let us know and we will cancel or adjust your order, and refund as required.

To find out the anticipated arrival time for specific items prior to ordering, please contact us by phone or email:

Phone +61 2 9264 3111, or 1800 4 BOOKS (1800 4 26657) if outside Sydney:
option 1 Abbey's Bookshop (Crime, History, Science, Kids & more) • info@abbeys.com.au
option 2 Language Book Centre (ESL & Foreign Languages) • language@abbeys.com.au
option 3 Galaxy Bookshop (Sci-fi, Fantasy, Romance, Graphic Novels) • sf@galaxybooks.com.au

QTY:

English

Springer Nature Switzerland AG
11 October 2018

Spectrum analysis, spectrochemistry, mass spectrometry; Inorganic chemistry; Organic chemistry; Organometallic chemistry; Proteins

Series: Springer Theses

This book examines Au (I, III) complexes that selectively attack and inhibit zinc finger proteins (ZnFs) for potential therapeutic use. The author explores gold(I)-phosphine, gold(III) complexes with N^N and C^N donors as inhibitors of the HIV-1 nucleocapsid protein (NCp7), in comparison to the human transcription factor Sp1. To determine the coordination sphere of the gold adducts formed by interaction with ZnFs, two innovative approaches are used, based on Travelling-Wave Ion Mobility coupled with Mass Spectrometry (TWIM-MS), and X-ray Absorption Spectroscopy. Both approaches are proven to yield valuable structural information regarding the coordination sphere of gold in the adducts. In addition, the organometallic compound [Au (bnpy)Cl2] is evaluated. The system is shown to be capable of inhibiting ZnFs by means of C–S coupling.

By: Raphael Enoque Ferraz de Paiva
Imprint: Springer Nature Switzerland AG
Country of Publication: Switzerland
Edition: 2018 ed.
Dimensions: Height: 235mm, Width: 155mm,
Weight: 459g
ISBN: 9783030008529
ISBN 10: 3030008525
Series: Springer Theses
Pages: 151
Publication Date: 11 October 2018
Audience: Professional and scholarly , Undergraduate
Format: Hardback
Publisher's Status: Active

"Au(I)-phosphine series design.- Probing the Protein: Ion Mobility Spectrometry.- Probing Gold: X-ray Absorption Spectroscopy.- Probing Cells: Cytotoxicity Evaluation.- Au(III) series with k2C,N and k2N,N' ligands.- ""Dual Probe"" X-ray Absorption Spectroscopy."