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Genetic Models of Down Syndrome by Bing Ye at Abbey's Bookshop,
Genetic Models of Down Syndrome
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Bing Ye Roger Reeves

Genetic Models of Down Syndrome

Bing Ye,  Roger Reeves

$278.95   $222.98

Hardback

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English
Springer International Publishing AG
31 January 2025
Medical research; Medical genetics; Genetics (non-medical); Developmental biology
Down syndrome is a textbook example of a chromosomal disorder and is common, occurring in 1 in 700 live births in the US. While there are many books previously published on the genetics of Down syndrome, and many studies in diverse species, this is the first book of its kind on the research models for Down syndrome that covers animal models. This book offers an in-depth introduction and discussion of the genetic models of down syndrome across diverse species, including rodents, zebrafish, drosophila, and human organoids. Authors use a cross-cutting approach to compare the strengths and weaknesses of each model system, explore how to use model organisms to study human diseases, and capture the status of the field. This book is a useful resource for biomedical researchers and students interested in using model systems to study Down syndrome and learn about Down syndrome and other chromosomal disorders.
Edited by:   ,
Imprint:   Springer International Publishing AG
Country of Publication:   Switzerland
Dimensions:   Height: 235mm,  Width: 155mm, 
ISBN:   9783031786105
ISBN 10:   3031786106
Pages:   274
Publication Date:  
Audience:   Professional and scholarly ,  Undergraduate
Format:   Hardback
Publisher's Status:   Active
Chapter 1: Introduction.- Chapter 2 : Rodent Models of Down Syndrome I: Mouse & Rat.- Chapter 3: Rodent Models of Down Syndrome II: Mouse.- Chapter 4: Rodent Models of Down Syndrome III: Mouse.- Chapter 5: Modeling Down Syndrome in C. elegans.- Chapter 6: Modeling Down Syndrome in Drosophila.- Chapter 7: Zebrafish Models of Down Syndrome.- Chapter 8: Using Human Brain organoids to Study Down Syndrome.- Chapter 9: Cellular Models: Stem Cells and other Cellular Models.-Chapter 10: Conclusions and Perspectives.

Bing Ye, PhD, is the Burton L. Baker Collegiate Professor of the Life Sciences at the University of Michigan Life Sciences Institute, and Professor of Cell and Developmental Biology at the University of Michigan Medical School. The focus of his lab's research is to address: how neuronal development contributes to the assembly and function of the nervous system, and how defects in this process lead to brain disorders. The Ye Lab uses both Drosophila and mice in their research, and take a multi-disciplinary approach that includes genetics, cell biology, developmental biology, biochemistry, advanced imaging (for neuronal structures and activity), electrophysiology, computation, and behavioral studies.

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