G Protein-Coupled Receptors

Structure, Function, and Ligand Screening

Tatsuya Haga, Shigeki Takeda

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English

CRC Press
19 September 2019

Pharmacology; Proteins

This book provides a broad base of knowledge of G-protein-coupled receptors. Useful at both the university and industrial levels, this book is of particular interest to those who are developing therapeutic approaches to diseases using drugs that influence receptor activation.

Edited by: Tatsuya Haga, Shigeki Takeda
Imprint: CRC Press
Country of Publication: United Kingdom
Dimensions: Height: 234mm, Width: 156mm,
Weight: 621g
ISBN: 9780367392376
ISBN 10: 0367392372
Pages: 336
Publication Date: 19 September 2019
Audience: Professional and scholarly , Undergraduate
Format: Paperback
Publisher's Status: Active

Screening of Ligands for GPCRs. Screening of Endogenous Ligands for Orphan GPCRs. Screening of Ligands for Human GPCRs by the Use of Receptor-Ga Fusion Proteins. Screening and Identification of Ghrelin, an Endogenous Ligand for the Growth-Hormone-Secretagogue Receptor. Ligand Screening of Olfactory Receptors. Functions and Regulation of GPCRs. Generation and Phenotypical Analysis of Muscarinic Acetylcholine Receptor Knockout Mice. Systematic Mutagenesis of M1 Muscarinic Acetylcholine Receptors. Analysis of the Regulation of Muscarinic Acetylcholine Receptors. Single-Molecule Analysis of Chemotactic Signaling Mediated by cAMP Receptor on Living Cells. Oligomerization of G Protein-Coupled Purinergic Receptors. Tertiary Structure of GPCRs and their Ligands. Methods and Results in X-ray Crystallography of Bovine Rhodopsin. Determination of Steric Structure of Muscarinic Ligands Bound to Muscarinic Acetylcholine Receptors: Approaches by TRNOE (Transferred Nuclear Overhauser Effect). Modeling of G Protein-Coupled Receptors for Drug Design.

Tatsuya Haga, Shigeki Takeda