Fmoc Solid Phase Peptide Synthesis: A Practical Approach

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W. Chan (School of Pharmaceutical Sciences, School of Pharmaceutical Sciences, University of Nottingham) Peter White (, Calbiochem/Novabiochem (UK), Nottingham)

Fmoc Solid Phase Peptide Synthesis

A Practical Approach

W. Chan (School of Pharmaceutical Sciences, School of Pharmaceutical Sciences, University of Nottingham), Peter White (, Calbiochem/Novabiochem (UK), Nottingham)

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English

Oxford University Press
01 March 2000

Chemistry; Polymer chemistry; Proteins; Biochemical immunology; Biotechnology

Series: Practical Approach Series

In the years since the publication of Atherton and Sheppard's volume, the technique of Fmoc solid-phase peptide synthesis has matured considerably and is now the standard approach for the routine production of peptides.

The basic problems at the time of publication of this earlier work have now for the most part, been solved.

As a result, innovators in the field have focussed their efforts to develop methodologies and chemistry for the synthesis of more complex structures.

The focus of this new volume is much broader, and covers the essential procedures for the production of linear peptides and more advanced techniques for preparing cyclic, side-chain modified, phospho- and glycopeptides.

Many other methods also deserving attention have been included: convergent peptide synthesis; peptide-protein conjugation; chemoselective ligation; and chemoselective purification.

The difficult preparation of cysteine and methionine-containing peptides is also covered, as well as methods for overcoming aggregation during peptide chain assembly.

Many of the techniques developed for the production of large arrays of peptides by parallel synthesis, such as t-bag, SPOT and PIN synthesis, have naturally been included.

Finally, a survey of available automated instrumentation has also been provided.

Edited by: W. Chan (School of Pharmaceutical Sciences School of Pharmaceutical Sciences University of Nottingham), Peter White (, Calbiochem/Novabiochem (UK), Nottingham)
Imprint: Oxford University Press
Country of Publication: United Kingdom
Volume: 222
Dimensions: Height: 234mm, Width: 157mm, Spine: 21mm
Weight: 1g
ISBN: 9780199637249
ISBN 10: 0199637245
Series: Practical Approach Series
Pages: 370
Publication Date: 01 March 2000
Audience: Professional and scholarly , Undergraduate
Format: Paperback
Publisher's Status: Active

Preface Sheppard: Introduction - a retrospective viewpoint White & Chan: Basic Principles Chan & White: Basic Procedures Albericio et al: Preparation and Handling of Peptides Containing Methionine and Cysteine Quibell & Johnson: Difficult Peptides Wellings et al: Synthesis of Modified Peptides White: Phosphopeptide Synthesis Kihlberg: Glycopeptide Synthesis Barlos & Gatos: Convergent Peptide Synthesis Drijfhout & Hoogerhout: Methods of Preparing Peptide-carrier Conguates Tam & Lu: Chemoselective and Orthogonal Ligation Techniques Mascagni: Purification of Large Peptides Using Chemioselective Tags Cammish & Kates: Instrumentation for Automated Solid-Phase Peptide Synthesis Doerner et al: Manual Multiple Synthesis Methods Appendix One Appendix Two Appendix Three Index

Reviews for Fmoc Solid Phase Peptide Synthesis: A Practical Approach

'covers the essential procedures for the production of linear peptides, and the techniques for preparing cyclic, side-chain modified, phospho-and glycopeptides' Sciences de la vie '..a completly fresh book...a goldmine...' European Petide Society