Covering pertinent basic science and offering today's most authoritative guidance on clinical management, Fetal Medicine, 3rd Edition, is a must-have resource for obstetricians and other healthcare professionals involved in care of the fetus. An international team of expert contributors delivers the knowledge and background you need to effectively diagnose and treat fetal disorders - everything from prenatal screening and diagnostic tests to common and rare prenatal conditions, early pregnancy loss, ethical issues, and much more.
Focuses on fetal medicine throughout, bringing you today's most reliable information in both basic science and clinical topics.
Offers updated information from cover to cover, including new coverage of genetics, embryology, and clinical management.
Features new self-assessment questions, new video clips, and new images throughout - for a total of nearly 1,000 photographs and line drawings, as well as more than 150 quick-reference tables.
Details fast-changing developments in fetal medicine, including advances in ultrasound imaging, cytogenetics, molecular biology, and biochemistry.
Helps you learn and retrieve complex information quickly thanks to succinct, highly structured text; key points at the beginning of each chapter; and concise chapter summaries.
Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.
New editor team - 3 new editors with an international approach - they will select qualified authors who can discuss the basic science as well as the clinical aspects of perinatal problems
Updated knowledge content - major areas of change are non-invasive prenatal testing (NIPT) and genetic testing - Ron Wapner is one of the leaders in these fields
Expert Consult access - individual electronic access for the first time
4-color design - current design is b&w so will update with new colors and colorize the drawings.
Section 1: Early Fetal Development 1 Early Concepts and Terminology, 2 Patricia Collins 2 Cellular Mechanisms and Embryonic Tissues, 6 Patricia Collins 3 Staging Embryos in Development and the Embryonic Body Plan, 23 Patricia Collins 4 Teratology, 30 Sarah G. Obican and Anthony R. Scialli 5 Early Pregnancy Failure, 38 Davor Jurkovic and Kuhan Rajah Section 2: The Placenta 6 The Immunology of Implantation, 48 Ashley Moffett, Y.W. Loke and Andrew Sharkey 7 Development of the Placenta and Its Circulation, 55 Caroline E. Dunk, Berthold Huppertz and John C. Kingdom 8 Placental Function in Maternofetal Exchange, 69 Colin Sibley and Mark Dilworth 9 Placental Pathology and Implications for Fetal Medicine, 78 Neil J. Sebire and John C. Kingdom Section 3: Fetal Physiology and Pathology 10 Development of the Heart and Cardiovascular System in Relation to Cardiac Abnormalities, 88 Michael Ashworth 11 Lung Growth and Maturation, 103 Richard Harding, Annie R.A. McDougall and Stuart B. Hooper 12 Development of the Kidneys and Urinary Tract in Relation to Renal Anomalies, 114 Paul J.D. Winyard 13 The Perinatal Postmortem Examination, 121 J. Ciaran Hutchinson, Susan C. Shelmerdine and Neil J. Sebire Section 4: Epidemiology 14 Epidemiologic and Research Methods in Fetal Medicine, 132 Cande V. Ananth and Alan T. Tita Section 5: Ethics 15 Ethical Issues in Maternal-Fetal Medicine, 139 Wybo J. Dondorp and Guido M. de Wert Section 6: Prenatal Screening and Diagnosis 16 Principles of Screening, 149 Joshua I. Rosenbloom and George A. Macones 17 Conveying Information About Screening and Diagnosis, 154 Jenny Hewison, Louise D. Bryant and Jane Fisher 18 Ultrasound and Biochemical Screening for Fetal Aneuploidy, 161 Howard Cuckle and Ran Neiger 19 Ultrasound Screening for Fetal Abnormalities in the First Trimester, 176 Caterina M. Bilardo and Frederick Ushakov 20 Evidence for Routine Ultrasound Screening for Fetal Abnormalities in the Second and Third Trimesters, 194 Yalda Afshar, Rashmi Rao, Anahit Martirosian and Lawrence D. Platt 21 Noninvasive Screening for Cytogenetic Disorders (Fetal Aneuploidy Including Microdeletions), 202 Karen Wou and Ronald J. Wapner 22 Noninvasive Prenatal Diagnosis for Single-Gene Disorders, 214 Melissa Hill and Lyn S. Chitty Contents Contents vii 23 Invasive Diagnostic Procedures, 225 Anthony O. Odibo and Ganesh Acharya 24 Prenatal Diagnosis of Chromosome Abnormalities, 233 Colleen G. Bilancia, Mythily Ganapathi and Brynn Levy 25 Advances in Molecular Genetics Including Fetal Sequencing, 247 Magdalena Walkiewicz and Ignatia B. Van den Veyver 26 Expanded Carrier Screening, 254 Liran Hiersch and Yuval Yaron 27 Prenatal Screening for Thalassemias, 263 Kwok Yin Leung, Patrick Au and Mary Tang Section 7: Diagnosis and Management of Fetal Malformations 28 Sonography of the Fetal Central Nervous System, 275 Luc De Catte, Bart De Keersmaecker, Luc Joyeux and Michael Aertsen 29 The Heart, 305 Christoph Wohlmuth and Helena M. Gardiner 30 Fetal Lung Lesions, 324 James Cook, Angela Yulia, Colin Wallis and Pranav P. Pandya 31 Congenital Diaphragmatic Hernia, 332 Francesca Maria Russo, Liesbeth Lewi, Jute Richter and Jan Deprest 32 Abdomen, 340 Jon Hyett 33 Kidney and Urinary Tract Disorders, 351 Roland Devlieger and An Hindryckx 34 Diagnosis and Management of Fetal Skeletal Abnormalities, 373 Lyn S. Chitty, Louise C. Wilson and Frederick Ushakov 35 Diagnosis and Management of Abnormalities of the Face, 402 Elisabeth de Jong-Pleij and Caterina M. Bilardo 36 Fetal Hydrops, 427 Sylvie Langlois and R. Douglas Wilson 37 Fetal Tumours, 443 Thomas R. Everett, Rosalind Pratt, Colin R. Butler, Richard J. Hewitt, Paolo De Coppi and Pranav P. Pandya 38 Open Fetal Surgery, 454 Luc Joyeux, Frank Van Calenbergh, Roland Devlieger, Luc De Catte and Jan Deprest Section 8: Diagnosis and Management of Other Fetal Conditions 39 Fetal Growth and Growth Restriction, 469 Emily J. Su and Henry L. Galan 40 Haemolytic Disease of the Fetus and Newborn, 484 Saul Snowise and Kenneth J. Moise Jr. 41 Fetal Platelet Disorders, 497 Dian Winkelhorst and Dick Oepkes 42 Fetal Infections, 508 Guillaume Benoist, Marianne Leruez-Ville and Yves Ville 43 Disorders of Amniotic Fluid, 526 Jan E. Dickinson 44 Multiple Pregnancy, 532 Sieglinde M. Müllers, Fionnuala McAuliffe and Fergal D. Malone 45 In Utero Stem Cell Transplantation, 554 Cecilia Götherström, Lilian Walther-Jallow and Magnus Westgren 46 Fetal Gene Therapy, 560 Anna L. David 47 The Developmental Origins of Health and Disease, 572 Scott W. White, Sara L. Hillman and John P. Newnham Section 9: Interface of Maternal, Fetal and Neonatal Medicine 48 Pharmacokinetics and Pharmacodynamics, 581 Lara S. Lemon, Raman Venkataramanan and Steve N. Caritis 49 Neonatal Management and Outcome in Extreme Prematurity, 588 Enrico Lopriore, Arjan B. Te Pas, Sylke Steggerda and Jeanine M. van Klink Online Materials Self-Assessment Spyros Bakalis, Frederick Ushakov and Pranav P. Pandya Index, 597
