Fatal Flaws: How a Misfolded Protein Baffled Scientists and Changed the Way We Look at the Brain

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Jay Ingram Lin Tang

Fatal Flaws

How a Misfolded Protein Baffled Scientists and Changed the Way We Look at the Brain

Jay Ingram, Lin Tang

$105.95

Hardback

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English

Yale University
19 March 2013

History of medicine; Neurology & clinical neurophysiology; Mathematics & Sciences

The story of the revolutionary science that is unraveling the mysteries of mad cow and other fatal brain diseases

Discovered and identified as the cause of mad cow disease only three decades ago, the prion is a protein molecule that, when misshapen in the brain, becomes fatal. Novel and controversial, prions have provoked a scientific revolution. They challenge the very foundations of biology: A disease-causing entity with no genetic material at all? A molecule capable of infecting, multiplying, and killing? This book recounts the birth of prion science and the imaginative detective work scientists have undertaken as they struggle to find the answers to devastating brain diseases from mad cow and Creutzfeldt-Jakob disease to Parkinson’s, Alzheimer’s, Lou Gehrig’s, and others. As in each of his best-selling books, Jay Ingram here makes complex scientific concepts accessible and shows how little-known events may have profound significance. He describes the development of prion science as a rough-and-tumble affair, with rivals, eccentrics, interfering governments, and brilliantly creative people all playing salient roles. Weaving biology, medicine, human tragedy, discovery, and bitter scientific competition into his account, he reveals the stunning potential of prion science, whose discoveries may unlock the answers to some of humankind’s most destructive diseases.

By: Jay Ingram
Illustrated by: Lin Tang
Imprint: Yale University
Country of Publication: United States
Dimensions: Height: 210mm, Width: 140mm, Spine: 25mm
Weight: 499g
ISBN: 9780300189896
ISBN 10: 0300189893
Pages: 288
Publication Date: 19 March 2013
Audience: College/higher education , Professional and scholarly , Further / Higher Education , Undergraduate
Format: Hardback
Publisher's Status: Active

Jay Ingram is an award-winning science author, writer, and broadcaster. He was co-host and producer of Discovery Channel Canada's Daily Planet from 1995 to 2011, and he is the author of eleven previous books. He lives in Alberta, Canada.

Reviews for Fatal Flaws: How a Misfolded Protein Baffled Scientists and Changed the Way We Look at the Brain

Jay Ingram's engrossing book is unbeatable for a balanced understanding of how mad cow disease might relate to other brain ailments. It's clear and concerned but never needlessly alarming. --John Rennie, former editor of Scientific American