Epigenetics in Cardiovascular Disease

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Yvan Devaux (Chair, EU-CardioRNA COST) Emma Louise Robinson (School of Medicine, Division of Cardiology, University of Colorado Denver, Anschutz Medical Campus, Aurora, Colorado, USA.)

Epigenetics in Cardiovascular Disease

Yvan Devaux (Chair, EU-CardioRNA COST), Emma Louise Robinson (School of Medicine, Division of Cardiology, University of Colorado Denver, Anschutz Medical Campus, Aurora, Colorado, USA.)

$299.95

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English

Academic Press Inc
10 March 2021

Genetics (non-medical); DNA & Genome

Series: Translational Epigenetics

Epigenetics in Cardiovascular Disease, a new volume in the Translational Epigenetics series, offers a comprehensive overview of the epigenetics mechanisms governing cardiovascular disease development, as well as instructions in research methods and guidance in pursing new studies. More than thirty international experts provide an (i) overview of the epigenetics mechanisms and their contribution to cardiovascular disease development, (i) high-throughput methods for RNA profiling including single-cell RNA-seq, (iii) the role of nucleic acid methylation in cardiovascular disease development, (iv) epigenetic actors as biomarkers and drug targets, (v) and the potential of epigenetics to advance personalized medicine. Here, readers will discover strategies to combat research challenges, improve quality of their epigenetic research and reproducibility of their findings. Additionally, discussion of assay and drug development for personalized healthcare pave the way for a new era of understanding in cardiovascular disease.

Edited by: Yvan Devaux (Chair EU-CardioRNA COST), Emma Louise Robinson (School of Medicine, Division of Cardiology, University of Colorado Denver, Anschutz Medical Campus, Aurora, Colorado, USA.)
Imprint: Academic Press Inc
Country of Publication: United States
Dimensions: Height: 235mm, Width: 191mm,
Weight: 970g
ISBN: 9780128222584
ISBN 10: 0128222581
Series: Translational Epigenetics
Pages: 498
Publication Date: 10 March 2021
Audience: Professional and scholarly , Undergraduate
Format: Paperback
Publisher's Status: Active

SECTION I INTRODUCTORY INFORMATION 1. The ever-growing burden of cardiovascular disease 2. Epigenetics concepts: An overview 3. From classical signaling pathways to the nucleus SECTION II EPIGENETICS MECHANISMS IN CARDIOVASCULAR DISEASE 4. DNA methylation in heart failure 5. Histone modifications in cardiovascular disease initiation and progression 6. RNA modifications in cardiovascular disease—An experimental and computational perspective 7. Regulatory RNAs in cardiovascular disease 8. Regulation of splicing in cardiovascular disease 9. Cardiac transcriptomic remodeling in metabolic syndrome 10. Sex differences in epigenetics mechanisms of cardiovascular disease 11. Epigenetics in cardiac development and human induced pluripotent stem cells SECTION III BIOMARKER VALUE 12. Peripheral blood DNA and RNA biomarkers of cardiovascular disease in clinical practice 13. Epigenetics and physical exercise 14. Long noncoding RNAs and circular RNAs as heart failure biomarkers 15. Artificial intelligence in clinical decision-making for diagnosis of cardiovascular disease using epigenetics mechanisms SECTION IV THERAPEUTIC POTENTIAL 16. Therapeutic strategies for modulating epigenetic mechanisms in cardiovascular disease SECTION V METHODOLOGICAL ISSUES 17. Single-cell RNA sequencing in cardiovascular science 18. Good laboratory and experimental practices for microRNA analysis in cardiovascular research 19. Analytical challenges in microRNA biomarker development: Best practices for analyzing microRNAs in cell-free biofluids 20. Concept of biological reference materials for RNA analysis in cardiovascular disease 21. Unbiased bioinformatics analysis of microRNA transcriptomics datasets and network theoretic target prediction

Dr Devaux is Chairing the EU-CardioRNA COST Action, an international network of 30 European countries focusing on Transcriptomics in Cardiovascular Disease. Dr Robinson is leading a Working Group on Dissemination activities in the Action. The network, with 100+ individual experts in the field of Epigenetics in cardiovascular disease, constitutes an invaluable reservoir of co-authors for the Volume.

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Epigenetics in Cardiovascular Disease

Yvan Devaux (Chair, EU-CardioRNA COST), Emma Louise Robinson (School of Medicine, Division of Cardiology, University of Colorado Denver, Anschutz Medical Campus, Aurora, Colorado, USA.)

$299.95

Paperback

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