Electrostatic Basis Of Biological Actions

Arieh Warshel (Univ Of Southern California, Usa)

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Hardback

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English

World Scientific Publishing Co Pte Ltd
02 January 2026

Physical chemistry; Molecular biology

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In this book, Nobel Laureate Arieh Warshel introduces the microscopic basis of electrostatic theory and the ways to evaluate electrostatic energies in macromolecules. Warshel rigorously develops the theoretical framework of electrostatics, introducing a hierarchy of models from all-atom representations to continuum approximations, critically evaluating their assumptions and limitations.

A major focus is placed on the electrostatic underpinnings of enzymatic catalysis, protein-ligand interactions, redox processes, and the folding and stability of proteins. The text also addresses specialized topics such as pKa calculations, ion and proton channels, and the dielectric behavior of proteins. Furthermore, we examine the electrostatic basis of molecular machines, signaling mechanisms (including G-proteins and Ras), GPCR activation, and cell-cell interactions.

By integrating detailed theoretical models with biological function, Warshel provides a unifying perspective that reshapes our understanding of biomolecular action. This work serves as both a definitive reference and a forward-looking framework, emphasizing the predictive power of physically consistent electrostatic models in elucidating life at the molecular level.

By: Arieh Warshel (Univ Of Southern California Usa)
Imprint: World Scientific Publishing Co Pte Ltd
Country of Publication: Singapore
ISBN: 9789819820603
ISBN 10: 981982060X
Pages: 292
Publication Date: 02 January 2026
Audience: College/higher education , Professional and scholarly , Primary , Undergraduate
Format: Hardback
Publisher's Status: Forthcoming