Directed C-H Bond Functionalization: Concepts and Applications

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Debabrata Maiti (Indian Institute of Technology Bombay, India) Supriya Rej (Indian Institute of Technology Dharwad, India)

Directed C-H Bond Functionalization

Concepts and Applications

Debabrata Maiti (Indian Institute of Technology Bombay, India), Supriya Rej (Indian Institute of Technology Dharwad, India)

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English

Blackwell Verlag GmbH
24 December 2025

Physical chemistry; Industrial chemistry; Chemical engineering; Materials science

Streamlined, cost-effective, and environmentally benign concepts for the synthesis of chemical building blocks and pharmaceuticals

Directed C—H Bond Functionalization summarizes recent advances in the field of selective and efficient C—H bond functionalization using directing groups.

Written by a team of experts in the field, Directed C—H Bond Functionalization includes information on:

History of the C—H bond activation and its discovery In-built functional group-directed C—H functionalization, proximal C—H bond functionalization, and template-assisted distal C—H bond functionalization Transient-directing group-assisted C—H bond functionalization and bifunctional non-covalent template-assisted C—H functionalization Redox catalytic methods and metal-free directed C—H functionalization reactions Industrial and synthetic application of directed C—H bond functionalization in organic synthesis, medicinal, and process chemistry

With its all-encompassing approach, Directed C—H Bond Functionalization is a timely, essential reference for synthetic chemists in academia and industry working in the fields of organic synthesis, catalysis, sustainable chemistry, and drug design.

Edited by: Debabrata Maiti (Indian Institute of Technology Bombay India), Supriya Rej (Indian Institute of Technology Dharwad, India)
Imprint: Blackwell Verlag GmbH
Country of Publication: Germany
Dimensions: Height: 244mm, Width: 170mm,
ISBN: 9783527354191
ISBN 10: 3527354190
Pages: 576
Publication Date: 24 December 2025
Audience: Professional and scholarly , College/higher education , Undergraduate , Further / Higher Education
Format: Hardback
Publisher's Status: Forthcoming

1. Introduction of C?H Bond Activation 2. Brief History of C?H Bond Activation and its Discovery 3. In-Built Functional Group-Directed C?H Functionalization 4. Traceless Directing Group in C?H Bond Functionalization 5. Removable Directing Group in Proximal C?H Functionalization 6. Removable Template-Assisted Distal C?H Functionalization 7. Transient Directing Group in C-H Bond Functionalization 8. Bifunctional Non-Covalent Template-Assisted C?H Functionalization 9. Redox Catalysis in Directed C?H Functionalization 10. Emerging Metal-Free Directed C?H Functionalization 11. Industrial and Synthetic Application of Directed C?H Bond Functionalization 12. Applications in Medicinal and Process Chemistry 13. Conclusion and Outlook

Debabrata Maiti is Professor and Institute Chair in the Department of Chemistry, IIT Bombay, India. His research interests are focused on the development of new and sustainable synthetic and catalytic methodologies. He is an Associate Editor for the Journal of Organic Chemistry (ACS). Supriya Rej is a Ramanujan faculty in the Department of Chemistry at IIT Dharwad, India. His current research focuses on bond activation and synthetic methodology development.