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Difficult to Treat Depression

A Carlat Guide

Chris Aiken

$139.95   $111.99

Paperback

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English
Carlat Publishing, LLC
10 November 2025
When Your Clinical Expertise Meets Complex Cases

Treatment-resistant depression challenges even the most experienced clinicians. When patients don't respond to first- and second-line treatments, the path forward requires sophisticated clinical reasoning, familiarity with advanced interventions, and a systematic approach to complex case management. This 348-page practical resource bridges the gap between research literature and clinical application, offering experienced psychiatrists a structured approach to patients who haven't responded to conventional treatments. Effective tools for your most challenging cases.

Inside this book, you'll find:

✔ A comprehensive framework for evaluating and defining treatment resistance, including diagnostic reconsideration and comorbidity assessment

✔ Evidence-based strategies for optimizing pharmacotherapy: augmentation, combination, and switching protocols backed by current research

✔ Practical guidance on advanced somatic treatments including ECT, TMS, ketamine/ esketamine, and emerging neuromodulation therapies

✔ Integration of psychotherapeutic approaches for treatment-resistant populations

✔ How to identify and address contributing factors: medical comorbidities, substance use, trauma, and medication interactions

✔ Pharmacogenomic testing and personalized medicine approaches: when to use them and how to interpret results

✔ Case studies illustrating decision-making in complex clinical scenarios

✔ Strategies for maintaining therapeutic alliance and managing patient and family expectations through prolonged treatment courses

✔ Updates on pipeline treatments and future directions in the field
By:  
Imprint:   Carlat Publishing, LLC
Dimensions:   Height: 229mm,  Width: 152mm,  Spine: 24mm
Weight:   626g
ISBN:   9798999881816
Pages:   348
Publication Date:  
Audience:   General/trade ,  ELT Advanced
Format:   Paperback
Publisher's Status:   Active

Dr. Aiken is the Editor in Chief of The Carlat Psychiatry Report; director of the Mood Treatment Center in North Carolina, where he maintains a private practice combining medication and therapy along with evidence-based complementary and alternative treatments; and Assistant Professor NYU Langone Department of Psychiatry. He has worked as a research assistant at the NIMH and a sub-investigator on clinical trials, and conducts research on a shoestring budget out of his private practice.

Reviews for Difficult to Treat Depression: A Carlat Guide

""An important and remarkably readable book, simultaneously broad, deep, and concise, offers the most comprehensive guidance I have seen for navigating the challenge of treating this population. It reflects not just evidence-based treatment, but a humane, integrative stance that invites clinicians to think across the biopsychosocial spectrum about this most vexing clinical problem. There is no other resource quite like it."" -David Mintz, MD, Director of Psychiatric Education at the Austen Riggs Center and author of Psychodynamic Psychopharmacology ""Distills an astounding amount of information into 48 clearly-written chapters, each of which is loaded with terrific and very practical advice."" -David Osser, MD, Associate Professor of Psychiatry at Harvard Medical School, author of Psychopharmacology Algorithms ""A thoughtful, scholarly, and reader-friendly summary of depression. This book will be a source of pragmatic insight and wisdom for any clinician who wrestles with the challenge of depressed patients who respond suboptimally to traditional antidepressant medications."" -Joseph F. Goldberg, MD, Clinical Professor of Psychiatry, Icahn School of Medicine, Deputy Editor-in-Chief, The Journal of Clinical Psychiatry, author of Practical Psychopharmacology ""A clear and concise survey of practical approaches to resistant depression, including both psychotherapy and medications, for busy clinicians."" -Conrad Swartz, MD, PhD, Professor Emeritus, Southern Illinois University, and author of Psychotic Depression


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