This expert volume in the Diagnostic Pathology series is an excellent point-of-care resource for practitioners at all levels of experience and training. Covering all aspects of benign and malignant lesions of lymph nodes, and extranodal lymphomas, as well as malignancies of spleen, it incorporates the most recent clinical, pathologic, and molecular knowledge in this challenging field to provide a comprehensive overview of all key issues relevant to today's practice. Richly illustrated and easy to use, the third edition of Diagnostic Pathology: Lymph Nodes and Extranodal Lymphomas is a one-stop reference for accurate, complete pathology reports, ideal as a day-to-day reference or as a reliable training resource.
Presents concise, extensive, and up-to-date information on more than 120 benign and malignant lesions of the lymph nodes, and covers extranodal lymphomas to help new and experienced surgical pathologists and hematopathologists alike identify crucial elements of each diagnosis and associated differential diagnoses
Provides clinical and histologic features, results of relevant ancillary studies, and a differential diagnosis for each entry
Features extensive updates throughout, reflecting the increasing importance of molecular markers for more precise diagnoses, and covering newly defined disease entities
Includes new chapters covering EBV(+) T- and NK-cell lymphoproliferative disorders of childhood, Erdheim-Chester disease, indolent T-cell lymphoproliferative disorder of the gastrointestinal tract, primary cutaneous acral CD8(+) lymphoma, primary cutaneous CD4(+) small/medium T-cell lymphoproliferative disorder, and primary cutaneous CD8(+) aggressive epidermotropic cytotoxic T-cell lymphoma, as well as new information on breast implant-associated anaplastic large cell lymphoma
Contains more than 3,100 high-quality clinical and histologic images, gross pathology images, radiologic images, micrographs, flow cytometry histograms, and full-color illustrations to help practicing and in-training pathologists reach a confident diagnosis
Includes updated criteria, terminology, and classifications using the latest World Health Organization classification terminology
Employs consistently templated chapters, bulleted content, key facts, a variety of test data tables, annotated images, and an extensive index for quick, expert reference at the point of care
Includes the enhanced eBook version, which allows you to search all text, figures, and references on a variety of devices
SECTION 1: REACTIVE NONSPECIFIC CHANGES 4 Reactive Follicular Hyperplasia Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD 10 Reactive Paracortical Hyperplasia Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD SECTION 2: INFECTIOUS CAUSES OF LYMPHADENITIS 20 Chronic Granulomatous Lymphadenitis L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD 28 Suppurative Lymphadenitis Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD 32 Mycobacterium tuberculosis Lymphadenitis L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD 40 Atypical Mycobacterial Lymphadenitis Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD 48 Mycobacterial Spindle Cell Pseudotumor L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD 52 Cat-Scratch Disease Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD 58 Bacillary Angiomatosis Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD 64 Lymphogranuloma Venereum Lymphadenitis Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD 68 Whipple Disease L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD 72 Syphilitic Lymphadenitis L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD 78 Infectious Mononucleosis L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD 84 Histoplasma Lymphadenitis L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD 90 Cryptococcus Lymphadenitis Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD 94 Toxoplasma Lymphadenitis Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD 100 Coccidioides Lymphadenitis L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD 108 Herpes Simplex Lymphadenitis L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD 114 Cytomegalovirus Lymphadenitis Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD 122 Human Immunodeficiency Virus Lymphadenitis Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD SECTION 3: REACTIVE LYMPHADENOPATHIES 134 Inflammatory Pseudotumor of Lymph Node L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD 142 Progressive Transformation of Germinal Centers L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD 148 Kikuchi-Fujimoto Disease L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD 158 Rosai-Dorfman Disease L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD 168 Kimura Disease Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD 176 Unicentric Hyaline Vascular Variant Castleman Disease L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD 182 Unicentric Plasma Cell Variant Castleman Disease L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD 188 Multicentric Castleman Disease L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD 196 Rheumatoid Arthritis-Related Lymphadenopathy L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD 204 Sarcoid Lymphadenopathy Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD 210 Dermatopathic Lymphadenopathy Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD 216 Hemophagocytic Lymphohistiocytosis L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD 226 Lymphadenopathy Associated With Joint Prostheses Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD 232 Lipid-Associated Lymphadenopathy Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD 236 Lymphadenopathy Secondary to Drug-Induced Hypersensitivity Syndrome L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD 244 IgG4-Related Disease Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD 254 Systemic Lupus Erythematosus 258 Sinus Histiocytosis Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD SECTION 4: HODGKIN LYMPHOMAS 264 Nodular Lymphocyte-Predominant Hodgkin Lymphoma L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD 276 Lymphocyte-Rich Classic Hodgkin Lymphoma L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD 284 Nodular Sclerosis Hodgkin Lymphoma Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD 294 Mixed Cellularity Hodgkin Lymphoma L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD 300 Lymphocyte-Depleted Hodgkin Lymphoma L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD SECTION 5: LEUKEMIA/LYMPHOMA OF IMMATURE B- OR T-CELL LINEAGE 308 B-Lymphoblastic Leukemia/Lymphoma Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD 318 T-Lymphoblastic Lymphoma/Leukemia L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD SECTION 6: NODAL B-CELL LYMPHOMAS 328 Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD 334 Richter Syndrome Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD 340 Lymphoplasmacytic Lymphoma and Waldenstroem Macroglobulinemia L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD 350 Nodal Marginal Zone B-Cell Lymphoma L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD 356 Nodal Follicular Lymphoma L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD 368 Pediatric-Type Follicular Lymphoma L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD 372 Mantle Cell Lymphoma L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD 378 Mantle Cell Lymphoma, Blastoid and Pleomorphic Variants L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD 384 Diffuse Large B-Cell Lymphoma, Not Otherwise Specified L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD 392 Diffuse Large B-Cell Lymphoma, Not Otherwise Specified, Immunoblastic L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD 398 T-Cell/Histiocyte-Rich Large B-Cell Lymphoma L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD 402 ALK(+) Large B-Cell Lymphoma L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD 408 EBV(+) Diffuse Large B-Cell Lymphoma L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD 414 HHV-8(+) Large B-Cell Lymphoma L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD 422 Burkitt Lymphoma Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD 430 High-Grade B-Cell Lymphoma Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD 436 B-Cell Lymphoma, Unclassifiable, Intermediate Between Diffuse Large B-Cell Lymphoma and Classic Hodgkin Lymphoma L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD SECTION 7: EXTRANODAL B-CELL LYMPHOMAS 448 Extranodal Marginal Zone Lymphoma of Mucosa- Associated Lymphoid Tissue (MALT Lymphoma) L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD 458 Extranodal Follicular Lymphoma Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD 470 Primary Cutaneous Follicle Center Lymphoma Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD 480 Primary Mediastinal (Thymic) Large B-Cell Lymphoma L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD 490 Primary Diffuse Large B-Cell Lymphoma of Central Nervous System L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD 500 Pyothorax-Associated Lymphoma L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD 506 Primary Cutaneous Diffuse Large B-Cell Lymphoma, Leg Type Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD 514 Plasmablastic Lymphoma L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD 524 Primary Effusion Lymphoma and Solid Variant of Primary Effusion Lymphoma L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD 532 Lymphomatoid Granulomatosis Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD 542 Intravascular Large B-Cell Lymphoma L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD 548 Plasmacytoma L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD 556 Diffuse Large B-Cell Lymphoma of Testis L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD 562 Splenic Marginal Zone Lymphoma L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD 570 Hairy Cell Leukemia Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD 580 Hairy Cell Leukemia Variant Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD 588 Splenic Diffuse Red Pulp Small B-Cell Lymphoma Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD 596 Diffuse Large B-Cell Lymphoma Arising in the Spleen L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD SECTION 8: NODAL T-CELL LYMPHOMAS 604 Peripheral T-Cell Lymphoma, Not Otherwise Specified L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD 614 Angioimmunoblastic T-Cell Lymphoma L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD 624 Adult T-Cell Leukemia/Lymphoma, HTLV-1(+) L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD 634 ALK(+) Anaplastic Large Cell Lymphoma L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD 640 ALK(-) Anaplastic Large Cell Lymphoma L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD SECTION 9: EXTRANODAL NK-/T-CELL LYMPHOMAS 648 Breast Implant-Associated Anaplastic Large Cell Lymphoma Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD 658 Extranodal NK-/T-Cell Lymphoma, Nasal Type L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD 666 Hepatosplenic T-Cell Lymphoma Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD 676 Enteropathy-Associated T-Cell Lymphoma L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD 684 Monomorphic Epitheliotropic Intestinal T-Cell Lymphoma Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD 692 Indolent T-Cell Lymphoproliferative Disorder of the Gastrointestinal Tract 696 Subcutaneous Panniculitis-Like T-Cell Lymphoma Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD 704 T-Cell Prolymphocytic Leukemia Involving Lymph Node and Other Tissues L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD 712 Primary Cutaneous ?/d T-Cell Lymphoma L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD 718 EBV(+) T- and NK-Cell Lymphoproliferative Disorders of Childhood L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD 722 Mycosis Fungoides L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD 736 Sezary Syndrome L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD 746 Primary Cutaneous Anaplastic Large Cell Lymphoma L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD 752 Lymphomatoid Papulosis L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD 758 Primary Cutaneous Acral CD8(+) Lymphoma 762 Primary Cutaneous CD8(+) Aggressive Epidermotropic Cytotoxic T-Cell Lymphoma 766 Primary Cutaneous CD4(+) Small/Medium T-Cell Lymphoproliferative Disorder SECTION 10: IMMUNODEFICIENCYASSOCIATED LYMPHOPROLIFERATIONS 772 Overview of Primary Immunodeficiency-Associated Lymphoproliferative Disorders L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD 778 Autoimmune Lymphoproliferative Syndrome L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD 790 Immunomodulating Agent-Associated Lymphoproliferative Disorders L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD 798 Posttransplant Lymphoproliferative Disorder, Early Lesions and Polymorphic L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD 808 Posttransplant Lymphoproliferative Disorder, Monomorphic L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD 818 EBV(+) Mucocutaneous Ulcer L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD SECTION 11: GRANULOCYTIC/HISTIOCYTIC TUMORS 824 Myeloid/Monocytic Sarcoma Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD 832 Blastic Plasmacytoid Dendritic Cell Neoplasm L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD 840 Blastic T/Myeloid Neoplasm Associated With ZMYM2-FGFR1 Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD 850 Cutaneous Mastocytosis Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD 854 Systemic Mastocytosis Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD 866 Histiocytic Sarcoma Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD 876 Follicular Dendritic Cell Sarcoma L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD 884 Interdigitating Dendritic Cell Sarcoma L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD 890 Langerhans Cell Histiocytosis Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD 902 Langerhans Cell Sarcoma L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD 910 Erdheim-Chester Disease L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD SECTION 12: NONHEMATOPOIETIC PROLIFERATIONS IN LYMPH NODE 916 Epithelial Inclusions in Lymph Node Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD 922 Nevus Cell Inclusions in Lymph Node Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD 926 Vascular Transformation of Lymph Node Sinuses L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD 930 Angiomyomatous Hamartoma L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD 934 Palisaded Myofibroblastoma L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD 938 Metastatic Kaposi Sarcoma Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD
L. Jeffrey Medeiros MD is a Professor of Pathology and the Chair of the Department of Hematopathology at the University of Texas MD Anderson Cancer Center in Houston, TX. His research interests include the diagnosis of lymphomas, including the use of histologic, imunnophenotypic, and molecular methods for diagnosis and prognosis, and most recent research efforts have focused on diffuse aggressive B-cell lymphomas. Dr. Medeiros is the returning co-lead author of Diagnostic Pathology: Lymph Nodes and Extranodal Lymphomas. Roberto N. Miranda, MD is a Professor of Hematopathology in the Division of Pathology/Lab Medicine at the University of Texas MD Anderson Cancer Center in Houston, TX. His research interests include T-cell lymphomas and he has developed an expertise in breast implant-associated anaplastic large cell lymphoma, a topic on which he has several landmark publications and book chapters, and on which he has lectured nationally and internationally. Dr. Miranda is the returning co-lead author of Diagnostic Pathology: Lymph Nodes and Extranodal Lymphomas.
