Developmental Oncology: Principles and Therapy of Cancers of Children and Young Adults

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Alex Kentsis Alejandro Gutierrez

Developmental Oncology

Principles and Therapy of Cancers of Children and Young Adults

Alex Kentsis, Alejandro Gutierrez

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English

Cold Spring Harbor Laboratory Press
26 March 2025

Oncology; Immunology; Genetics (non-medical)

Summary
Details

A variety of cancers

affect children and young adults, including leukemias, sarcomas, and

tumors of the nervous system. These are caused by errors that occur

during development and arise in specific populations of cells that

accumulate somatic mutations in early life.

Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine

provides a comprehensive review of our understanding of cancers that

occur during childhood and in young adults, the mechanisms underlying

their appearance, and current and future treatment strategies. Recent

discoveries show these young-onset cancers are fundamentally

developmental in origin. The contributors review how developmental

processes in the growing body generate cell states that are susceptible

to tumorigenesis in particular types of cells. They discuss the bases

for genetic predisposition, endogenous and exogenous somatic mutational

processes, epigenetic regulation, and the influence of the immune and

tissue microenvironments.

In addition, the authors examine the

multiple therapeutic approaches used to target young-onset cancers, such

as combination treatments and immunologic, metabolic, and cellular

therapies. Cancer surveillance is also covered, as well as the unique

challenges of pediatric cancer drug development. The volume will

therefore be an essential reference for cancer biologists, practicing

oncologists, and those interested in how we can drive progress in cancer

treatment.

By: Alex Kentsis, Alejandro Gutierrez
Imprint: Cold Spring Harbor Laboratory Press
Dimensions: Height: 254mm, Width: 178mm, Spine: 19mm
Weight: 794g
ISBN: 9781621825050
ISBN 10: 1621825051
Pages: 300
Publication Date: 26 March 2025
Audience: General/trade , ELT Advanced
Format: Hardback
Publisher's Status: Active