Developmental and Reproductive Toxicology

A Practical Approach, Third Edition

Ronald D Hood (Northport, Alabama, USA)

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Hardback

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English

CRC Press
14 December 2011

Medicine: general issues; Reproductive medicine; Toxicology (non-medical); Developmental biology

The purpose of this third edition of Developmental and Reproductive Toxicology is to provide a practical guide to developmental and reproductive toxicology in a regulatory environment. In addition to a comprehensive update of current chapters, the third edition been revised to reflect recent changes in the field. It contains new chapters that reflect emerging topics of interest, including testing of biologics (including vaccines), nonhuman primates as nonclinical models, developmental immunotoxicity testing, in vitro assays (such as use of zebrafish and stem cells, as well as high throughput screening), in silico systems modelling, evaluating mechanisms of reproductive toxicity, in-depth coverage of neurobehavioral testing, and testing under the EU’s REACH regulations, as well as updated chapters on nonclinical juvenile toxicity testing, endocrine disruptor screening, and on functional and computational genomics.

The study of hazard and risk associated with exposure to toxicants during prenatal development has been expanded in recent years to include effects on development until the time of puberty. Concern over the adverse effects of chemical or physical agents on the reproductive processes of both sexes has increased, and progress has been made in identifying the causes and mechanisms eliciting congenital defects and determining the genetic, epigenetic, and environmental factors involved. This book provides up-to-date guidance on the use and interpretation of the newest research techniques in developmental and reproductive toxicology, as well as the more traditional approaches.

Developmental and Reproductive Toxicology, Third Edition:

Contains valuable insights gained from hands-on experience, together with a critical evaluation of current testing strategies. Includes guidance for the design, conduct, and interpretation of tests in all areas of developmental and reproductive toxicity. Contains reprinted guidelines from major regulatory agencies, as well as terminology for description of developmental abnormalities in laboratory animals, for easy reference. Provides guidance for planning and conducting preclinical toxicity studies and follow-up studies, and interpreting their results in a regulatory environment.

This book continues to be the ideal practical reference for developmental and reproductive toxicologists who perform research in industry, government, and academia and for anyone who intends to enter these research areas.

Edited by: Ronald D Hood (Northport Alabama USA)
Imprint: CRC Press
Country of Publication: United Kingdom
Edition: 3rd edition
Dimensions: Height: 246mm, Width: 189mm, Spine: 56mm
Weight: 2.018kg
ISBN: 9781841847771
ISBN 10: 1841847771
Pages: 870
Publication Date: 14 December 2011
Audience: Professional and scholarly , Undergraduate
Format: Hardback
Publisher's Status: Active

Ronald D. Hood is a Toxicology Consultant at Ronald D. Hood & Associates and works at the University of Alabama, Tuscaloosa, USA.

Reviews for Developmental and Reproductive Toxicology: A Practical Approach, Third Edition

This is a great foundation book for trainees pursuing research in reproductive toxicology and serves as the perfect reference during the course of study. The field of reproductive toxicology is changing and this update is critical and mostly timely. Doody's Review Service