Development of In-Tether Carbon Chiral Center-Induced Helical Peptide: Methodology and Applications

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Kuan Hu

Development of In-Tether Carbon Chiral Center-Induced Helical Peptide

Methodology and Applications

Kuan Hu

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English

Springer Verlag, Singapore
27 January 2022

Organic chemistry; Biochemistry; Proteins; Biotechnology; Materials science

Series: Springer Theses

This book focuses on the development of stapled peptides, a novel molecular modality used to regulate aberrant intracellular protein–protein interactions (PPIs). The author designs and presents a novel helical peptide stabilization methodology by constructing a chiral cross-linker moiety, namely “chiral center induced peptide helicity (CIH)”. The book demonstrates that a precisely positioned carbon chiral center on tether can decisively determine the secondary structure of a peptide, and that the R-configured peptide is helical, while the S-configured peptide is non-helical. Further, it reports that helicity-enhanced R isomer peptides displayed significantly enhanced cell permeability and target binding affinity, as well as tumor inhibition efficiency, in comparison to S isomer peptides. The book will not only advance readers’ understanding of the basic principle of stapled peptides, but also accelerate the clinical transformation of stapled peptide drugs.

By: Kuan Hu
Imprint: Springer Verlag, Singapore
Country of Publication: Singapore
Edition: 2021 ed.
Dimensions: Height: 235mm, Width: 155mm,
Weight: 197g
ISBN: 9789813366152
ISBN 10: 981336615X
Series: Springer Theses
Pages: 102
Publication Date: 27 January 2022
Audience: Professional and scholarly , Undergraduate
Format: Paperback
Publisher's Status: Active

Introduction.- Method to construct in-tether chiral center constrained helical peptide.- Application in disrupting p53/MDM2 protein-protein interactions.- Fabrication of nanomaterials with in-tether chiral center constrained helical peptide.