Dendritic Spines

Rafael Yuste (Columbia University)

$130

Paperback

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English

MIT Press
22 August 2023

Neurology & clinical neurophysiology; Neurosciences

"A leading neurobiologist explores the fundamental function of dendritic spines in neural circuits by analyzing different aspects of their biology, including structure, development, motility, and plasticity.

A leading neurobiologist explores the fundamental function of dendritic spines in neural circuits by analyzing different aspects of their biology, including structure, development, motility, and plasticity.

Most neurons in the brain are covered by dendritic spines, small protrusions that arise from dendrites, covering them like leaves on a tree. But a hundred and twenty years after spines were first described by Ram n y Cajal, their function is still unclear. Dozens of different functions have been proposed, from Cajal's idea that they enhance neuronal interconnectivity to hypotheses that spines serve as plasticity machines, neuroprotective devices, or even digital logic elements. In Dendritic Spines, leading neurobiologist Rafael Yuste attempts to solve the ""spine problem,"" searching for the fundamental function of spines. He does this by examining many aspects of spine biology that have fascinated him over the years, including their structure, development, motility, plasticity, biophysical properties, and calcium compartmentalization. Yuste argues that we may never understand how the brain works without understanding the specific function of spines. In this book, he offers a synthesis of the information that has been gathered on spines (much of which comes from his own studies of the mammalian cortex), linking their function with the computational logic of the neuronal circuits that use them. He argues that once viewed from the circuit perspective, all the pieces of the spine puzzle fit together nicely into a single, overarching function. Yuste connects these two topics, integrating current knowledge of spines with that of key features of the circuits in which they operate. He concludes with a speculative chapter on the computational function of spines, searching for the ultimate logic of their existence in the brain and offering a proposal that is sure to stimulate discussions and drive future research."

By: Rafael Yuste (Columbia University)
Imprint: MIT Press
Country of Publication: United States
Dimensions: Height: 229mm, Width: 178mm,
Weight: 454g
ISBN: 9780262549004
ISBN 10: 026254900X
Pages: 280
Publication Date: 22 August 2023
Recommended Age: From 18 years
Audience: College/higher education , Professional and scholarly , Further / Higher Education , Undergraduate
Format: Paperback
Publisher's Status: Active

Preface xi 1 Introduction 1 2 Discovery 9 3 Structure 19 4 Molecules 47 5 Development 73 6 Motility 103 7 Calcium 133 8 Plasticity 161 9 Physiology 181 10 Computation 197 References 219 Source Notes 253 Index 255

Rafael Yuste is Professor in the Departments of Biological Sciences and Neuroscience at Columbia University, where he is HHMI Investigator and Codirector of the Kavli Institute for Brain Circuits.

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Dendritic Spines

Rafael Yuste (Columbia University)

$130

Paperback

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