Death Receptors and Cognate Ligands in Cancer

Holger Kalthoff

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English

Springer-Verlag Berlin and Heidelberg GmbH & Co. K
14 March 2012

Cellular physiology; Oncology; Biochemistry; Cellular biology (cytology)

Series: Results and Problems in Cell Differentiation

Summary
Details

Death receptors play a central role in directing apoptosis in mammalian cells. This process of active cell death is important for a number of biological processes, e.g. for the regulation of the immune system. Death receptors are cell surface receptors that transmit apoptotic signals initiated by corresponding death ligands. Many complex signaling pathways are activated and apoptosis is the final result of a complex biochemical cascade of events.

Besides their role in the induction of cell death, evidence now exists that death receptors are able to activate several non-apoptotic signaling pathways which, depending on cellular context, may lead to apoptosis resistance, secretion of pro-inflammatory proteins, proliferation and invasive growth of cancer cells.

This book looks at the molecular basis of death receptor signaling and the role of death receptors in cancer development.

Edited by: Holger Kalthoff
Imprint: Springer-Verlag Berlin and Heidelberg GmbH & Co. K
Country of Publication: Germany
Edition: 2009 ed.
Volume: 49
Dimensions: Height: 235mm, Width: 155mm, Spine: 16mm
Weight: 456g
ISBN: 9783642260766
ISBN 10: 3642260764
Series: Results and Problems in Cell Differentiation
Pages: 280
Publication Date: 14 March 2012
Audience: Professional and scholarly , Undergraduate
Format: Paperback
Publisher's Status: Active