Dancing protein clouds: Intrinsically disordered proteins in health and disease, Part A

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Vladimir N Uversky (Professor, Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, USA)

Dancing protein clouds

Intrinsically disordered proteins in health and disease, Part A

Vladimir N Uversky (Professor, Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, USA)

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English

Academic Press Inc
12 September 2019

Proteins; Molecular biology

Series: Progress in Molecular Biology and Translational Science

"""Dancing protein clouds: Intrinsically disordered proteins in the norm and pathology"" represents a set of selected studies on a variety of research topics related to intrinsically disordered proteins. Topics in this update include structural and functional characterization of several important intrinsically disordered proteins, such as 14-3-3 proteins and their partners, as well as proteins from muscle sarcomere; representation of intrinsic disorder-related concept of protein structure-function continuum; discussion of the role of intrinsic disorder in phenotypic switching; consideration of the role of intrinsically disordered proteins in the pathogenesis of neurodegenerative diseases and cancer; discussion of the roles of intrinsic disorder in functional amyloids; demonstration of the usefulness of the analysis of translational diffusion of unfolded and intrinsically disordered proteins; consideration of various computational tools for evaluation of functions of intrinsically disordered regions; and discussion of the role of shear stress in the amyloid formation of intrinsically disordered regions in the brain."

Volume editor: Vladimir N Uversky (Professor Department of Molecular Medicine Morsani College of Medicine University of South Florida USA)
Imprint: Academic Press Inc
Country of Publication: United States
Dimensions: Height: 229mm, Width: 151mm,
Weight: 800g
ISBN: 9780128168516
ISBN 10: 012816851X
Series: Progress in Molecular Biology and Translational Science
Pages: 424
Publication Date: 12 September 2019
Audience: Professional and scholarly , Undergraduate
Format: Hardback
Publisher's Status: Active

1. Protein intrinsic disorder and structure-function continuum Vladimir N. Uversky 2. Intrinsic disorder associated with 14-3-3 proteins and their partners Nikolai N. Sluchanko and Diego M. Bustos 3. Intrinsically disordered proteins and phenotypic switching: Implications in cancer Vivek Kulkarni and Prakash Kulkarni 4. Translational diffusion of unfolded and intrinsically disordered proteins Irina V. Nesmelova, Daria L. Melnikova, Venkatesh Ranjan and Vladimir D. Skirda 5. Intrinsically disordered proteins in the formation of functional amyloids from bacteria to humans Anamika Avni, Hema M. Swasthi, Anupa Majumdar and Samrat Mukhopadhyay 6. Intrinsically disordered proteins in various hypotheses on the pathogenesis of Alzheimer's and Parkinson's diseases Orkid Coskuner and Vladimir N. Uversky 7. Shear-induced amyloid formation of IDPS in the brain Conrad N. Trumbore 8. Role of intrinsic disorder in muscle sarcomeres Dmitri Tolkatchev, Garry E. Smith Jr. and Alla S. Kostyukova 9. Computational prediction of functions of intrinsically disordered regions Akila Katuwawala, Sina Ghadermarzi and Lukasz Kurgan 10. The dark proteome of cancer: Intrinsic disorderedness and functionality of HIF-1a along with its interacting proteins Neha Garg, Prateek Kumar, Kundlik Gadhave and Rajanish Giri

Vladimir N. Uversky is a Professor at the Department of Molecular Medicine, University of South Florida, USA. He obtained B.S. and M.S. degrees in Physics from Leningrad State University in Russia in 1986, then completed Ph.D. and Doctor of Sciences (D.Sc.) degrees in Physics and Mathematics (field of study - Biophysics) at the Moscow Institute of Physics and Technology (1991) and the Institute Experimental and Theoretical Biophysics of the Russian Academy of Sciences (1998), respectively. In 1998, he moved to the University of California Santa Cruz to study protein folding, misfolding, protein conformation diseases, and protein intrinsic disorder phenomena. In 2004, he was invited to join the Indiana University School of Medicine to primary work on intrinsically disordered proteins, and since 2010 has been on faculty at the University of South Florida. He has authored over 850 scientific publications and edited several books and book series on protein structure.