Cytochrome P450

In Vitro Methods and Protocols

Zhengyin Yan, Gary W. Caldwell

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English

Springer-Verlag New York Inc.
10 July 2021

Pharmacology; Biochemistry; Enzymology

Series: Methods in Pharmacology and Toxicology

Summary
Details

This collection explores detailed experimental protocols necessary for setting up a variety of in vitro cytochrome P450 (CYP) assays that are vital in selecting drug candidates in a drug discovery pipeline. Major factors affecting drug metabolism include CYP expression levels, kinetic parameters for individual CYP enzymes, CYP inhibition and induction, time-dependent inhibition (TDI), CYP stability, non-CYP stability, UDP-glucuronosyltransferases (UGT) stability, excretion mechanisms, and drug-drug interactions (DDI), all addressed in this volume. Written for the Methods in Pharmacology and Toxicology series, chapters include helpful background information on the in vitro assay, a list of all the materials, reagents, and equipment necessary to carry out the assay, a step-by-step protocol, notes containing common and unexpected experimental problems in the assay, as well as references containing important supplementary reading. Authoritativeand practical, Cytochrome P450: In Vitro Methods and Protocols serves as a key guide for researchers in the area of discovery and development of new medicines.

Edited by: Zhengyin Yan, Gary W. Caldwell
Imprint: Springer-Verlag New York Inc.
Country of Publication: United States
Edition: 2021 ed.
Dimensions: Height: 254mm, Width: 178mm,
Weight: 932g
ISBN: 9781071615416
ISBN 10: 1071615416
Series: Methods in Pharmacology and Toxicology
Pages: 379
Publication Date: 10 July 2021
Audience: Professional and scholarly , Undergraduate
Format: Hardback
Publisher's Status: Active