Creutzfeldt-Jakob disease: The Neurodegenerative Spongiform Disease in Search of a Cure

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Alain L Fymat

Creutzfeldt-Jakob disease

Name: Creutzfeldt-Jakob disease
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ISBN: 9781834189819

The Neurodegenerative Spongiform Disease in Search of a Cure

Alain L Fymat

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English

Tellwell Talent
03 January 2026

Diseases & disorders; Popular medicine & health

Creutzfeldt-Jakob disease is a very rare incurable neurodegenerative disease leading to fatal brain disorder. It is believed to be caused by abnormal prion proteins that trigger normal proteins to misfold, causing brain damage. Its symptoms are mental deterioration, neurological problems, and dementia. It progresses rapidly, with a median survival time of 4-5 months. Brain biopsy or post-mortem examination is needed for confirmation of the disease.

In general, proteins fold into discrete units that perform distinct cellular functions, but some proteins are also capable of forming an infectious conformational state known as a prion. Although often viewed in the context of infectious diseases, prions are more loosely defined by their ability to catalytically convert other native state versions of the same protein to an infectious conformational state. Prions are an enigma amongst infectious disease agents as they lack a genome yet confer specific pathologies. They have caused us to question the universality of the central dogma of molecular biology and to revisit it. Prion diseases affect both humans and animals, the latter including the food-producing ruminant species.

This volume is essentially interested in Creutzfeldt-Jakob disease in humans and will not dwell on other inherited prion diseases such as Gerstmann-Sträussler-Scheinker syndrome (a rare, inherited prion disease with a slow progression) and fatal familial insomnia (a very rare, inherited prion disease characterized by severe insomnia and progressive neurodegeneration). It discusses prions and their purported causative diseases as well as prion-mimic diseases. It also presents the needed primers of the scientific bases of the disease and suggests what can be done about it. Interestingly, Parkinson's may be viewed as a prion disease and Alzheimer's as a double-prion disease, although there is no general agreement on this view in the broader scientific community. Further, whereas prions are said to be the 'cause' of prion diseases, I rather view such proteins merely as the by-products of a run-away autoimmune disease, as elaborated in my previous volumes on neurodegenerative diseases.

By: Alain L Fymat
Imprint: Tellwell Talent
Dimensions: Height: 279mm, Width: 216mm, Spine: 36mm
Weight: 1.619kg
ISBN: 9781834189819
ISBN 10: 1834189810
Pages: 524
Publication Date: 03 January 2026
Audience: General/trade , ELT Advanced
Format: Paperback
Publisher's Status: Active

DR. ALAIN L. FYMAT, BA, BS, MA, MS, PhD, PhD, MYNAS, MEUAS is a medical-physical scientist and an educator. He is the current President/ CEO and Institute Professor at the International Institute of Medicine & Science with a previous appointment as Executive Vice President/Chief Operating Officer and Professor at the Weil Institute of Critical Care Medicine, both Institutes located in California, U.S.A. He was formerly Professor of Radiology, Radiological Sciences, Radiation Oncology, Critical Care Medicine, and Physics at several U.S. and European Universities. Earlier, he was Deputy Director (Western Region) of the U.S. Department of Veterans Affairs (Office of Research Oversight). At the Loma Linda Veterans Affairs Medical Center, he was Scientific Director of Radiology, Director of the Magnetic Resonance Imaging Center and, for a time, Acting Chair of Radiology. Previously, he was Director of the Division of Biomedical and Biobehavioral Research at the University of California at Los Angeles/Drew University of Medicine and Science.DR. FYMAT was also Scientific Advisor to the U.S. National Academy of Sciences, National Research Council, for its postdoctoral programs tenable at the California Institute of Technology and Member of the Advisory Group for Research & Development, North Atlantic Treaty Organization (NATO). He is Health Advisor to the American Heart & Stroke Association, Coachella Valley Division, California. He is a frequent Keynote Speaker and Scientific Organizing Committee member at several international scientific/medical conferences. He has lectured extensively in the U.S.A, Canada, Europe, Asia, and Africa. He has published more than 600 scholarly scientific publications and books. He is also Editor-in-Chief, Honorable Editor or Editor of numerous medical/scientific Journals to which he regularly contributes. He is a member of the New York Academy of Sciences and the European Union Academy of Sciences, a Board member of several institutions, and a reviewer for the prestigious UNESCO Newton Prize, United Kingdom National Commission for UNESCO.DR. FYMAT's research interests are currently focused on neurodegenerative diseases; genetics, epigenetics & ecogenetics; nanomedicine & nanobiotechnology; epidemics, and pandemics (COVID), as represented in part in his latest books.