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Colony-Stimulating Factors

Molecular & Cellular Biology, Second Edition,

John M. Garland



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CRC Press
10 October 2019
Concentrating on proven data and adopting a structure-function approach, this text provides grounding for an intricate understanding of the molecular biology, physiological mechanisms, and routine clinical use in disease settings of colony-stimulating factors (CSFs). This edition includes eight additional chapters, with updates of recently-discovered and established CSFs, each indexed individually.
By:   John M. Garland
Imprint:   CRC Press
Country of Publication:   United Kingdom
Edition:   2nd New edition
Dimensions:   Height: 254mm,  Width: 178mm, 
Weight:   1.070kg
ISBN:   9780367400958
ISBN 10:   0367400952
Pages:   584
Publication Date:   10 October 2019
Audience:   College/higher education ,  Primary
Format:   Paperback
Publisher's Status:   Active
Overview: introduction to the haematopoietic system; surrogate assays for haematopoietic stem cell activity; receptors for haematopoietic regulators; regulation of the cell cycle by kinases and cyclins; gene organization and regulation; cytokines and apoptosis - the mechanism of regulation of cell death; haematopoietic microenvironments; extracellular matrix- and membrane-bound cytokines; transfection of stem cells and gene therapy. Colony-stimulating factor: granulocyte-macrophage colony-stimulating factor and its receptor; granulocyte colony-stimulating factor; human interleukin-3 - an overview; macrophage colony-stimulating factor; erythropoietic; the role of interleukin-4 in normal and malignant human haematopoietic effects of interleukin-1; kit-ligand-stem cell factor; interleukin-5. Cytokines: macrophages inflammatory protein-1 alpha; transforming growth factor-beta, tumour necrosis factor-alpha, and macrophage inflammatory protein-1 alpha are bidirectional regulators of haematopoietic cell growth; leukaemia inhibitory factor; interleukin-12 in haematopoiesis; ex vivo expansion of haematopoietic stem and progenitor cells; clinical use of cytokines.

John M. Garland\,

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