The book is essential for anyone in the pharmaceutical field, as it offers invaluable insights into the innovative world of cocrystals, their design principles, experimental techniques, and practical applications that can significantly enhance drug development and address critical industry challenges.
Co-Crystals in Pharmaceutical Sciences: Design to Applications is a comprehensive exploration of pharmaceutical cocrystals that introduces their scope and potential impact on drug development. This volume highlights the structural characteristics influencing cocrystals and delves into design principles and molecular interactions. Focus is placed on the advantages and challenges of integrating in-silico techniques for screening, which accelerates cocrystal discovery. Detailed coverage of experimental techniques, validation, and process optimization provides a solid foundation for readers. The book uniquely explores herbal and drug-drug cocrystals, showcasing synergies between traditional herbal medicine and modern pharmaceuticals. Scaling up cocrystal synthesis and potential commercial opportunities are examined in depth. Chapters on pharmaceutical applications emphasize how cocrystals address solubility, stability, and therapeutic challenges, with real-world examples illustrating their impact. The role of cocrystals in enhancing mechanical properties for more efficient formulations is discussed, and insights into the patent landscape and regulatory considerations round out the book, making it an indispensable resource for researchers and industry professionals alike.
Audience
Botanists, biologists, pharmaceutical professionals, drug delivery experts, and materials scientists studying pharmaceutical sciences.
Edited by:
Inderbir Singh Bakshi (Chitkara College of Pharmacy Chitkara University Punjab India),
Subrata Mallick (School of Pharmaceutical Sciences,
Siksha 'O' Anusandhan (Deemed to be University),
Odisha,
India),
Ritu Rathi (Chitkara College of Pharmacy,
Chitkara University,
Punjab,
India),
Shilpi Harnal
Imprint: Wiley-Scrivener
Country of Publication: United States
Weight: 771g
ISBN: 9781394302475
ISBN 10: 1394302479
Pages: 400
Publication Date: 23 May 2025
Audience:
Professional and scholarly
,
Undergraduate
Format: Hardback
Publisher's Status: Active
Preface xiii 1 Pharmaceutical Cocrystals: Introduction, History and Applications 1 Oluwatoyin A. Odeku and Olufunke D. Akin-Ajani 1.1 Introduction 2 1.2 History 3 1.3 Applications of Cocrystals in Pharmaceutical Sciences 4 1.4 Challenges in the Development of Cocrystals 12 1.5 Marketed Products 17 1.6 Future of Pharmaceutical Cocrystals 17 1.7 Conclusion 18 2 Design and Structural Characteristics of Pharmaceutical Cocrystals 29 Harpreet Singh, Bhuvnesh Kumar Singh, Anil Kumar, Arvind Kumar, Arun Kumar Mishra, Ritu Rathi and Inderbir Singh 2.1 Introduction 30 2.2 Design of Pharmaceutical Cocrystals 34 2.3 Structural Characteristics of Pharmaceutical Cocrystals 44 2.4 Challenges and Future Directions in Pharmaceutical Cocrystal 46 2.5 Conclusion 48 3 Advancements in Computational Screening Methods for Pharmaceutical Cocrystals 55 Maan Singh, Abhishek Mali, Madhukiran Dhondale, Ashish Kumar Agrawal, Amrit Paudel and Dinesh Kumar 3.1 Introduction 56 3.2 Experimental Screening of Cocrystals 59 3.3 Computational Method for Screening Cocrystals 62 3.4 Recent Trends in Cocrystal Screening and Future Approach 78 3.5 Conclusion 81 4 Preparation Techniques of Pharmaceutical Cocrystals 93 Nikita Thakur, Mansi Prashar, Sukhvir Kaur, Neelima Dhingra, Manish Kumar, Ritu Rathi, Inderbir Singh and Poonam Arora 4.1 Introduction 94 4.2 Cocrystal Preparation Techniques 95 4.3 Optimization Parameters for Cocrystal Formation 108 4.4 Future Perspectives and Challenges 112 5 A Brief on Analytical and Characterization Techniques for Evaluation of Pharmaceutical Cocrystals 121 Suraj R. Chaudhari, Shashikant B. Bagade, Sonali V. Chaudhari and Atul A. Shirkhedkar 5.1 Introduction 122 5.2 Analytical Techniques 123 5.3 Physicochemical Characterization of Cocrystals 131 5.4 Conclusion 143 6 Advancements and Applications of Herbal Cocrystals 153 Rajat Goyal, Pankaj Popli, Kashish Wilson, Hitesh Chopra, Sonia Dhiman and Sumeet Gupta 6.1 Introduction 154 6.2 Benefits and Applications of Herbal Cocrystals 163 6.3 Challenges and Limitations of Herbal Cocrystals, Solubility Issues, and Incompatibilities 164 6.4 Reported Herbal Cocrystals 166 6.5 Future Perspectives and Trends 166 6.6 Conclusion 178 7 Drug-Drug Cocrystals: Advancements and Applications 189 Ritu Rathi, Sushant Sharma, Siddhartha Gautham Pal, Rohil Panwar, Taruna, Rakesh Pahwa and Inderbir Singh 7.1 Introduction 190 7.2 Reported Drug-Drug Cocrystals for Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) 199 7.3 Reported Drug-Drug Cocrystals for Anticancer Drugs 202 7.4 Reported Drug-Drug Cocrystals for Antituberculosis Drugs 206 7.5 Reported Drug-Drug Cocrystals for Diuretics 209 7.6 Reported Drug-Drug Cocrystals for Miscellaneous Drugs 212 7.7 Patent Perspectives 214 7.8 Marketed Product 218 7.9 Conclusion 218 8 Scaling Up Pharmaceutical Cocrystals: Exploring Commercial Opportunities and Industrial Prospective 231 Kampanart Huanbutta, Tanikan Sangnim, Ritu Rathi and Inderbir Singh 8.1 Introduction 232 8.2 Challenges and Considerations in Cocrystal Scale-Up 233 8.3 Promising Methods for Cocrystal Scale-Up 235 8.4 Quality-By-Design Approaches (QbD) in Cocrystallization Manufacturing 243 8.5 Process Analytical Technology in Scale-Up Cocrystallization Process 244 8.6 Commercial Opportunities for Cocrystals 246 8.7 Future Directions and Outlook 246 8.8 Conclusion 249 9 Pharmaceutical Cocrystals for Solubility Enhancement of Drugs 257 Mouli Das, Sk Habibullah, Tanisha Das and Subrata Mallick 9.1 Introduction 258 9.2 Why Solubility Enhancement is Important? 259 9.3 Factors Affecting Solubility 260 9.4 Solubility and Bioavailability 263 9.5 Permeability and Cocrystallization 264 9.6 Enhancing Solubility through Cocrystallization 265 9.7 Conclusion 282 10 Pharmaceutical Cocrystals for Improving Physicochemical Properties of Drugs: Enhancement of Therapeutic Efficacy 293 Debabrata Ghosh Dastidar, Arpan Datta, Sanchari Bhattacharya and Moumita Chowdhury 10.1 Introduction 294 10.2 Preparation and Characterization Methods for Cocrystals 295 10.3 Enhancement of Therapeutic Efficacy with Cocrystals 297 10.4 Regulatory Considerations for Cocrystal Approval 319 10.5 Conclusion and Future Aspects 322 11 Application of Pharmaceutical Cocrystals in Improving Mechanical Properties and Stability 329 Sushant Sharma, Ritu Rathi, Ayushi Taneja, Poonam Arora and Inderbir Singh 11.1 Introduction 330 11.2 Pharmaceutical Cocrystals Improve Mechanical Properties 332 11.3 Pharmaceutical Cocrystals Improving Stability 341 11.4 Conclusion and Future Prospective 344 12 Patents and Regulatory Considerations of Pharmaceutical Cocrystals 357 Ritu Rathi, Ritamay Sau, Rakesh K. Sindhu, Harpreet Singh and Inderbir Singh 12.1 Introduction 358 12.2 Generic Concept of Pharmaceutical Cocrystals 365 12.3 Data Consideration Using Pharmaceutical Cocrystals for Abridged Application 367 12.4 Patent on Cocrystals 370 12.5 Conclusion 373 Acknowledgment 374 References 374 Index 379
Inderbir Singh, PhD, is a professor and the Assistant Dean of Research at Chitkara College of Pharmacy, Chitkara University, India. He has published eight books, 25 book chapters, and 180 papers in peer-reviewed journals. He also has 11 utility patents and 15 design registrations under review and has been granted three patents. His research interests include gastroretentive drug delivery systems, biopolymers, biomaterials, modified polymers in drug delivery, pharmaceutical cocrystals, the SeDeM expert system, and 3D printing technology. Subrata Mallick, PhD, is a professor and the Head of the Department of Pharmaceutics in the School of Pharmaceutical Sciences, Siksha ‘O’ Anusandhan University, Odisha, India, with 26 years of teaching, research, and industry experience. He has published over 100 papers in international journals, six books, over 130 conference abstract proceedings, and five scientific articles, in addition to serving as an editorial board member for several international journals. His areas of interest include transdermal drug delivery systems, transmucosal drug delivery systems, powder compaction, drug degradation kinetics and stabilization, and drug-drug and drug-excipient interactions. Ritu Rathi, PhD, is a PhD research scholar at Chitkara College of Pharmacy, Chitkara University, India, with five years of research experience in the field of pharmaceutical sciences. In addition to her active pharmaceutical research, she has published 17 articles and book chapters in various national and international journals, applied for three utility patents, and been granted two design registrations. Her research interests include pharmaceutical cocrystals, solubility enhancement techniques, herbal bioactives, and in-silico modeling techniques.
