Chromatin: Structure, Function, and History

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Randall H. Morse (Chief, Laboratory of Molecular Genetics, Wadsworth Center, NY State Department of Health and Professor, Department of Biomedical Sciences, UAlbany School of Public Health, USA)

Chromatin

Structure, Function, and History

Randall H. Morse (Chief, Laboratory of Molecular Genetics, Wadsworth Center, NY State Department of Health and Professor, Department of Biomedical Sciences, UAlbany School of Public Health, USA)

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English

Academic Press Inc
20 June 2024

Molecular biology

Chromatin: Structure, Function, and History brings the reader up to date on the remarkable progress made in chromatin research over the course of the past 50 years. Coverage includes the basics of chromatin biology, beginning with the discoveries that culminated in the recognition of the nucleosome as the basic subunit of chromatin. Chromatin folding, nucleosome positioning, and histone variants are discussed, as well as research on chromatin modifications and remodeling, which exploded in the early to mid-1990s and led to widespread interest in epigenetics. Considerable attention is given to methods and experiments that led to key insights, and recent developments such as the use of genome-wide approaches and innovations in imaging approaches are also emphasized. By providing historical background together with detailed discussion of contemporary studies, the book aims to instill in the reader an appreciation not only of our current knowledge of chromatin structure and function, but also of the remarkable path that has taken chromatin to the forefront of modern research.

By: Randall H. Morse (Chief Laboratory of Molecular Genetics Wadsworth Center NY State Department of Health and Professor Department of Biomedical Sciences UAlbany School of Public Health USA)
Imprint: Academic Press Inc
Country of Publication: United States
Dimensions: Height: 229mm, Width: 152mm,
Weight: 1.170kg
ISBN: 9780128148099
ISBN 10: 0128148098
Pages: 584
Publication Date: 20 June 2024
Audience: Professional and scholarly , Undergraduate
Format: Paperback
Publisher's Status: Active

Part I. Chromatin structure 1. Early history 2. Unveiling the nucleosome 3. Chromatin folding 4. Nucleosome positioning 5. Histone variants Part II. Chromatin function 6. Chromatin remodeling 7. Chromatin modifications 8. Chromatin and transcription

Randall H. Morse's interest in chromatin originated with an undergraduate course in molecular genetics in 1975. After finishing his graduate studies in biophysical chemistry at Caltech, Dr. Morse worked as a postdoctoral fellow at Columbia University and the National Institutes of Health. He continued to conduct research on chromatin and transcription in his own lab at the Wadsworth Center in Albany, New York. Additionally, he has taught chromatin structure and function to graduate students in the Department of Biomedical Sciences at the University at Albany School of Public Health since 1994. Dr. Morse has contributed his expertise and research on chromatin structure and function to numerous conferences. Furthermore, he has written articles and reviews on this subject and has received several competitive grants to fund his research.

Reviews for Chromatin: Structure, Function, and History

""...explores the complexities of chromatin structure and its sophisticated mechanisms of modulation.... [It] takes an explicitly historical approach to describing how available knowledge and technology interact to both govern as well as limit the course of scientific advancements in biomolecular research. It represents an ideal vehicle for teaching students and other trainees about both the nature of chromatin and the biomolecular research enterprise, as well as an informative and pleasant read for the expert investigator.... A moderate number of informative figures supplement the text, while each chapter cites a rich array of source material.... Among this array of choices, this book stands out by virtue of its attractive, and well-executed, blending of scientific knowledge with human and technical science history. [A]n exceptionally readable book whose contents should be accessible to a wide range of potential readers."" --©Doody’s Review Service, 2024, Peter J. Kennelly, PhD (Virginia Tech)