Chemical Glycobiology

Synthesis, Manipulation and Applications of Glycans

Barbara Imperiali (MIT, Cambridge, MA, USA)

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English

Academic Press Inc
20 September 2017

Enzymology; Molecular biology; Biotechnology

Series: Methods in Enzymology

Chemical Glycobiology, Volume 597, the latest release in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. This volume, the first on chemical glycobiology, contains comprehensive chapters on the Discovery of New Glycosidases from Metagenomic Libraries, Structure-guided directed evolution of glycosidases: A case study in engineering a blood group antigen-cleaving enzyme, A Pipeline for Studying and Engineering Single-Subunit Oligosaccharyltransferases, Directed evolution of glycopeptides using mRNA display, Chemoenzymatic Synthesis and Applications of Prokaryote-Specific UDP-Sugars, and Biosynthesis of Legionaminic Acid and its Incorporation into Glycoconjugates.

Readers will find the latest information on this developing area of research, as reported by leaders in the field.

Volume editor: Barbara Imperiali (MIT Cambridge MA USA)
Imprint: Academic Press Inc
Country of Publication: United States
Dimensions: Height: 229mm, Width: 151mm,
Weight: 450g
ISBN: 9780128114698
ISBN 10: 012811469X
Series: Methods in Enzymology
Pages: 430
Publication Date: 20 September 2017
Audience: Professional and scholarly , Undergraduate
Format: Hardback
Publisher's Status: Active

1. Discovery of New Glycosidases from Metagenomic Libraries Stephen George Withers, Zach Armstrong and Peter Rahfeld 2. Structure-guided directed evolution of glycosidases: A case study in engineering a blood group antigen-cleaving enzyme David Kwan 3. A Pipeline for Studying and Engineering Single-Subunit Oligosaccharyltransferases Matt DeLisa 4. Directed evolution of glycopeptides using mRNA display Isaac Krauss 5. Chemoenzymatic Synthesis and Applications of Prokaryote-Specific UDP-Sugars Barbara Imperiali and Cristina Zamora 6. Biosynthesis of Legionaminic Acid and its Incorporation into Glycoconjugates Michel Gilbert, Ian Schoenhofen and Martin Young 7. Syntheses of fluorescent gangliosides for the studies of raft domains Makoto Kiso 8. Profiling of Sugar Nucleotides Rob Field 9. Chemoenzymatic glycan remodeling of natural and recombinant glycoproteins Lai-Xi Wang 10. Glycoengineered Outer Membrane Vesicles as a platform for vaccine development Mario Feldman 11. Identification and Design of Synthetic B Cell Epitopes for Carbohydrate-based Vaccines Peter Seeberger and Felix Broecker 12. Strategies in the Design and Use of Synthetic ‘Internal Glycan’ Vaccines Ben Davis 13. Evaluation of Virus Like Particle Based Tumor-Associated Carbohydrate Immunogen in a Mouse Tumor Model Xuefei Huang, Xuanjun Wu and Suttipun Sungsuwan

Barbara Imperiali is Professor of Biology and Chemistry at MIT, USA

Reviews for Chemical Glycobiology: Synthesis, Manipulation and Applications of Glycans

"Praise for the Series: ""Should be on the shelves of all libraries in the world as a whole collection."" --Chemistry in Industry ""The work most often consulted in the lab."" --Enzymologia ""The Methods in Enzymology series represents the gold-standard."" --Neuroscience"