Cardiovascular Biology of Purines

Name: Cardiovascular Biology of Purines
Price: 583.25 AUD
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ISBN: 9781461375630

Geoffrey Burnstock, James G. Dobson Jr., Bruce T. Liang , Joel Linden

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English

Springer-Verlag New York Inc.
08 October 2012

Physiology; Cardiovascular medicine; Surgery; Cardiothoracic surgery

Series: Developments in Cardiovascular Medicine

Summary
Details

Following many years when a great deal of attention was

directed towards the intracellular roles of purines, there is

expanding interest in the field of extracellular purinergic

signalling. In this book we focus on the actions of purines in

cardiovascular biology, where it is clear that they play major roles

in both normal and pathophysiological conditions. Activation of

different purinoceptor subtypes by purines can regulate cardiac contractility and electrical activity, modulate catecholamine-mediated

responses both pre- and post-junctionally, trigger and mediate

ischaemic preconditioning, cause vasodilation and vasoconstriction and

enhance endothelial proliferation and apoptosis as well as inhibit

platelet and neutrophil function. This book covers the cardiovascular

actions mediated by the major P1 and P2 subclasses of purinoceptors

and emphasizes the interactions between these two signalling systems. Cardiovascular Biology of Purines covers topics ranging from

molecular and cellular to systemic and clinical. It also aims to

highlight how basic advances have led to the identification of novel

targets for cardiovascular therapeutic developments. We hope that our

book will prove to be timely and helpful.

Edited by: Geoffrey Burnstock, James G. Dobson Jr., Bruce T. Liang, Joel Linden
Imprint: Springer-Verlag New York Inc.
Country of Publication: United States
Edition: Softcover reprint of the original 1st ed. 1998
Volume: 209
Dimensions: Height: 235mm, Width: 155mm, Spine: 20mm
Weight: 599g
ISBN: 9781461375630
ISBN 10: 1461375630
Series: Developments in Cardiovascular Medicine
Pages: 374
Publication Date: 08 October 2012
Audience: Professional and scholarly , Undergraduate
Format: Paperback
Publisher's Status: Active