Carbohydrate-Based Vaccines

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Rene Roy (Professor of Chemistry, Professor of Chemistry, Universite du Quebec a Montreal)

Carbohydrate-Based Vaccines

Rene Roy (Professor of Chemistry, Professor of Chemistry, Universite du Quebec a Montreal)

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English

Oxford University Press Inc
29 October 2009

Chemistry; Biochemistry; Carbohydrates

Series: ACS Symposium Series

This book is the first of its kind entirely dedicated to carbohydrate vaccines written by renowned scientists with expertise in carbohydrate chemistry and immunochemistry. It covers the synthesis of carbohydrate antigens related to bacteria and parasites such as: Heamophilus influenza, Streptococcus pnemoniae, Shigella flexneri, Candida albicans, Mycobacterium tuberculosis, and Chlamydia. The first three chapters are of wide interest as they cover fundamental concerns in new vaccine developments. The first one presents the immune system and how carbohydrate antigens are processed before protective antibodies are produced. It also illustrates antigen presentation in the context of major histocompatibility complexes (MHCs). The second chapter describes regulatory issues when carbohydrate vaccines are involved while the third one discuss several techniques used in conjugation chemistry and the implication of certain chemical linkages that may induce unexpected anti-linker antibodies. This section will be particularly appealing for those involved in drug-conjugate design, pro-drug developments, and drug vectorization. The book concludes with one chapter that illustrates the principle through which peptide antigens can functionally mimic carbohydrate epitopes, thus, unraveling the potential for peptide surrogates as replacement for complex carbohydrate structures.

This book is unique in that it covers all aspects related to carbohydrate vaccines including the success story with the first semi-synthetic bacterial polysaccharide vaccine against Heamophilus influenza type b responsible for pneumonia and meningitis, liable for more than 600,000 infant deaths worldwide in developing countries. The book also presents regulatory issues and will thus be vital for government agencies approving candidate vaccines. It widely covers synthetic methodologies for the attachment of carbohydrate antigens to peptides and immunogenic protein carriers. Vaccines against bacterial antigens, cancer, and parasites are also discussed by worldwide experts in this field in details. No other book contains such a wide panel of different expertise. It will also be useful to students and researchers involved with the immunology of forreings antigens and how the under appreciated carbohydrate antigens are processed by the immune system.

Edited by: Rene Roy (Professor of Chemistry Professor of Chemistry Universite du Quebec a Montreal)
Imprint: Oxford University Press Inc
Country of Publication: United States
Volume: 989
Dimensions: Height: 235mm, Width: 159mm, Spine: 23mm
Weight: 656g
ISBN: 9780841239838
ISBN 10: 0841239835
Series: ACS Symposium Series
Pages: 396
Publication Date: 29 October 2009
Audience: Professional and scholarly , Undergraduate
Format: Hardback
Publisher's Status: Active

Preface 1: T-cell immunity of carbohydrates 2: The Regulatory Framework for Glycoconjugate Vaccines 3: Conjugation methods towards synthetic vaccines 4: Haemophilus influenzae type b conjugate vaccine with a synthetic capsular polysaccharide antigen. Chemical view 5: Immunology of Experimental Synthetic Carbohydrate-Protein Conjugate Vaccines against Streptococcus pneumoniae Serotypes 6: From epitope characterization to the design of semi-synthetic glycoconjugate vaccines against Shigella flexneri 2a infection 7: Automated Oligosaccharide synthesis to create vaccines for malaria and other parasites 8: A uniquely small, protective carbohydrate epitope may yield a conjugate vaccine for Candida albicans 9: Sudies toward the Development of anti-tuberculosis vaccines based on mycobacterial lipoarabinomannan 10: The Lipoarabinomannan glycolipid of Mycobacterium tuberculosis: Progress in total synthesis via n-pentenyl orthoesters 11: Lipopolysaccharide antigens of Chlamydia 12: Synthetic Carbohydrate-based Antitumor Vaccines 13: Synthetic Glycopeptides for the Construction of Anticancer Vaccines 14: Glycopeptide based cancer vaccines: the rule of synthesis and structural definition 15: Peptide mimics of bacterial polysaccharides: Potential for discriminating vaccines

René Roy is Professor in the Department of Chemistry at the Université du Québec à Montréal (UQAM). He is a native of Montreal.