Cancer Metabolism

Historical Landmarks, New Concepts, and Opportunities

Ralph J Deberardinis, Karen Vousden, Navdeep Chandel

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English

Cold Spring Harbor Laboratory Press
19 November 2024

Metabolism; Oncology; Endocrinology

Summary
Details

Cancer cells often display metabolic changes that distinguish them from normal cells in the body. Their preference for glycolysis over aerobic respiration even in the presence of oxygen was first observed over a century ago; however, it is only over the past two decades that researchers have begun to characterize all the pathways involved and investigate the therapeutic possibilities. Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine reviews our understanding of the diversity of metabolic changes seen in cancer cells and their roles in sustaining tumor survival and proliferation. The contributors cover the new technologies being used to monitor metabolism in cells, the Warburg effect and the importance of mitochondria, metabolic signaling, and the importance of redox reactions and antioxidants. Other chapters examine the role of the tumor microenvironment, metal ions, and the immune system. The book also discusses the role of diet and how studies of patients are revealing how metabolic reprogramming occurs. It will thus be of interest not only to biochemists and oncologists but to all biologists interested in how the behavior of cells is regulated and coordinated.

By: Ralph J Deberardinis, Karen Vousden, Navdeep Chandel
Imprint: Cold Spring Harbor Laboratory Press
Dimensions: Height: 254mm, Width: 178mm, Spine: 33mm
Weight: 1.243kg
ISBN: 9781621824701
ISBN 10: 1621824705
Pages: 438
Publication Date: 19 November 2024
Audience: General/trade , ELT Advanced
Format: Hardback
Publisher's Status: Active