Biomolecular Imaging at High Spatial and Temporal Resolution In Vitro and In Vivo

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Thomas Harry Sharp

Biomolecular Imaging at High Spatial and Temporal Resolution In Vitro and In Vivo

Thomas Harry Sharp

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English

Springer International Publishing AG
23 August 2016

Microscopy; Analytical chemistry; Life sciences: general issues; Materials science

Series: Springer Theses

As part of a collaboration between two different groups in chemistry and biochemistry, Thom Sharp presents here his thesis work on the development of new methods for cryoelectron microscopy. Throughout his Ph.D., Thom had to master a whole range of techniques including modelling, molecular biology and microscopy. Using these skills to tackle an outstanding problem, the pursuit of high-resolution structures of peptide-based materials, Thom highlights in this thesis his newly developed methods for analysing and processing this particular type of electron microscopy data. This thesis gives the first molecular description of a de-novo designed peptide-based material. In general, this research will have a huge impact on the peptide assembly field, and also in electron microscopy as it introduces new methods and approaches, all of which are Thom's inventions and are described in this thesis.

By: Thomas Harry Sharp
Imprint: Springer International Publishing AG
Country of Publication: Switzerland
Edition: Softcover reprint of the original 1st ed. 2014
Dimensions: Height: 235mm, Width: 155mm, Spine: 9mm
Weight: 2.642kg
ISBN: 9783319350233
ISBN 10: 3319350234
Series: Springer Theses
Pages: 150
Publication Date: 23 August 2016
Audience: Professional and scholarly , Undergraduate
Format: Paperback
Publisher's Status: Active

Biomolecules & Microscopy.- Materials and Methods.- Experimental Methods.- Imaging Methods.- Experimental Results.- Towards an Atomistic Structure of a De Novo Designed Peptide Fibre.- Developing Novel Probes for Correlative Light Electron Microscopy.

Thom Sharp completed his bachelor’s degree in Biochemistry at the University of Bristol, with a year spent a year working at AstraZeneca. He continued in Bristol for his PhD in bionanotechnology, which was performed under the supervision of Dek Woolfson, a protein design chemist, and Paul Verkade, an electron microscopist. Thom is currently at the University of Oxford, where he is developing DNA-templated protein arrays to increase the throughput of single-particle analysis.