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English
Oxford University Press Inc
01 August 1996
This book presents a critical assessment of progress on the use of nuclear magnetic resonance spectroscopy to determine the structure of proteins, including brief reviews of the history of the field along with coverage of current clinical and in vivo applications. The book, in honor of Oleg Jardetsky, one of the pioneers of the field, is edited by two of the most highly respected investigators using NMR, and features contributions by most of the leading workers in the field.

It will be valued as a landmark publication that presents the state-of-the-art perspectives regarding one of today's most important technologies.

Edited by:   , , , , , ,
Imprint:   Oxford University Press Inc
Country of Publication:   United States
Dimensions:   Height: 241mm,  Width: 159mm,  Spine: 22mm
Weight:   642g
ISBN:   9780195094688
ISBN 10:   0195094689
Pages:   374
Publication Date:  
Audience:   Professional and scholarly ,  Undergraduate
Format:   Hardback
Publisher's Status:   Active
SECTION I: History of the Biological NMR Spectroscopy 1: O. Jardetsky: Simple Insights from the Beginnings of Magnetic Resonance in Molecular Biology 2: M. Cohn: Choice of Problems in the Early Days of Biochemical NMR 3: R.G. Shulman: Early Days of Biochemical NMR 4: J.J.H. Ackerman: William D. Phillips Memorial Lecture SECTION II: Protein Structural Studies 5: M.R. Gryk & O. Jardetsky: Flexibility & Function of the Escherichia coli trp Repressor 6: M.J. Revington, W. Lee, and C.H. Arrowsmith: Heteronuclear Strategies for the Assignment of Larger Protein/DNA Complexes 7: C. Ho and H.-W. Kim: Design of Novel Hemoglobins 8: C.M. Dobson: The Role of NMR Spectroscopy in Understanding how Proteins Fold 9: G.C.K. Roberts, L.-Y. Lian, I.L. Barsukov, S. Modi, and W.U. Primrose: NMR Approaches to Understanding Protein Specificity 10: A.P. Hinck, W.F. Walkenhorst, D.M. Truckses, and J.L. Markley: NMR and Mutagenesis Investigations of a Model Cis:Trans Peptide Isomerization Reaction 11: S.J.Opella, L.E. Chirlian, and B. Bechinger: A Solid State NMR Approach to Structure Determination of Membrane Associated Peptides and Proteins 12: K. Akasaka, T, Yamaguchi, H. Yamada, Y. Kamatari, and T. Konno: NMR Approach to the Heat-, Cold-, and pressure-Induced Unfolding of Proteins 13: F. Mari, X. Xie, J.H. Simpson, and D.J. Nelson: Multidimensional NMR Investigation of the Neurotoxic Peptide mastoparan in the Absence and Presence of Calmodulin 14: Y. Arata: NMR of Larger Proteins 15: K.S. Matthews: Selective Chemical Deuteration of Aromatic Amino Acids 16: T. Jardetsky: The Interactions of Antigens and Superantigens with the Human Class II Major Histocompatibility complex Molecule HLA-DR1 17: W.N. Lipscomb: Chorismate Mutase, Essentially a Template Enzyme SECTION III: Nucleic Acids 18: R. Chen, D. Fink, and R.B. Altman: Computing the Structure of Large Complexes 19: D. Wemmer: Design and Characterization of New Sequence Specific DNA Ligands 20: C. Milhe, A. Lane, and J.F. Lefévre: Determination by 1H NMR of a Slow Conformational Transition and Hydration Change in the Consensus TATAAT Pribnow Box SECTION IV: In Vivo Spectroscopy 21: P.J. Cozzone, J. Vion-Dury, S. Confort-Gouny, F. Nicoli, A.-M. Salvan, and S. Lamoreux: Clinicians Need Localized Proton MRS of the Brain in the Management of HIV-related Encephalopathies 22: O. Kaplan and J.S. Cohen: Nuclear Magnetic Resonance Spectroscopy Studies of cancer Cell Metabolism 23: L. Litt, M.T. espanol, Y. Xu, Y. Cohen, L.-H. chang, P.R. Weinstein, P.H. Chan, and T.L. James: Ex Vivo Multinuclear NMR Spectroscopy of Perfused respiring Rat Brain Slices

Reviews for Biological NMR Spectroscopy

a useful collection. . . . The book may serve as an effective reference work with a potpourri of collected papers. . . . a well-referenced and handy text with and excellent overview of biological NMR spectroscopy. --Concepts in Magnetic Resonance Excellent. . . .This text should be required reading for all scientists interested in, or involved with, the application of NMR to biological problems. The text provides not only a clear overview of the state of the art in the field but also, in my opinion, an equally important overview of the history of the field. --Journal of Medicinal Chemistry Nuclear magnetic resonance spectroscopy is an extremely powerful tool in characterizing a variety of biological problems, ranging from protein structure determination, to characterization of enzyme reaction mechanisms, to in vivo metabolism and medical imaging. . . .Overall, the book is quite enjoyable and it essentially accomplishes its aim to provide 'a contemporary overview of the legacy of these early (NMR) experiments'. . .in modern structural biology. --Applied Spectroscopy The contributors survey the historical development and roles of NMR in a group of introductory essays, and further explore the contemporary research being done in the field with specific discussions. --SciTech Book News a useful collection. . . . The book may serve as an effective reference work with a potpourri of collected papers. . . . a well-referenced and handy text with and excellent overview of biological NMR spectroscopy. --Concepts in Magnetic Resonance Excellent. . . .This text should be required reading for all scientists interested in, or involved with, the application of NMR to biological problems. The text provides not only a clear overview of the state of the art in the field but also, in my opinion, an equally important overview of the history of the field. --Journal of Medicinal Chemistry Nuclear magnetic resonance spectroscopy is an extremely powerful tool in characterizing a variety of biological problems, ranging from protein structure determination, to characterization of enzyme reaction mechanisms, to in vivo metabolism and medical imaging. . . .Overall, the book is quite enjoyable and it essentially accomplishes its aim to provide 'a contemporary overview of the legacy of these early (NMR) experiments'. . .in modern structural biology. --Applied Spectroscopy The contributors survey the historical development and roles of NMR in a group of introductory essays, and further explore the contemporary research being done in the field with specific discussions. --SciTech Book News


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