Biochemistry of Lipids, Lipoproteins and Membranes

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Neale Ridgway (Departments of Pediatrics and Biochemistry and Molecular Biology, Dalhousie University, Halifax, Nova Scotia, Canada) Roger McLeod (Department of Biochemistry and Molecular Biology, Dalhousie University, Halifax, Nova Scotia, Canada)

Biochemistry of Lipids, Lipoproteins and Membranes

Neale Ridgway (Departments of Pediatrics and Biochemistry and Molecular Biology, Dalhousie University, Halifax, Nova Scotia, Canada), Roger McLeod (Department of Biochemistry and Molecular Biology, Dalhousie University, Halifax, Nova Scotia, Canada)

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English

Elsevier Science Publishing Co Inc
23 August 2021

Biophysics; Biochemistry; Lipids; Cellular biology (cytology)

Biochemistry of Lipids, Lipoproteins and Membranes, Seventh Edition serves as a comprehensive, general reference book for scientists and students studying lipids, lipoproteins and membranes. Here, across 19 chapters, leaders in the field summarize fundamental concepts, recent research developments, data analysis, and implications for human disease and intervention. Topics discussed include lipid biology in both prokaryotes and eukaryotes, fatty acid synthesis, desaturation and elongation, and pathways leading to synthesis of complex phospholipids, sphingolipids and their structural variants. Chapters also examine how bioactive lipids are involved in cell signaling, with an emphasis on disease implications and pathological consequences.

As the field advances, each chapter in this new edition has been fully revised to address emerging topics, with all-new coverage of lipid droplets and their role as regulatory organelles for energy homeostasis, as well as their relationship to obesity, liver disease and diabetes. Evolving research in fatty acid handling and storage in eukaryotes is also discussed in-depth, with new sections addressing fatty acid uptake, activation and lipolysis.

Edited by: Neale Ridgway (Departments of Pediatrics and Biochemistry and Molecular Biology Dalhousie University Halifax Nova Scotia Canada), Roger McLeod (Department of Biochemistry and Molecular Biology, Dalhousie University, Halifax, Nova Scotia, Canada)
Imprint: Elsevier Science Publishing Co Inc
Country of Publication: United States
Edition: 7th edition
Dimensions: Height: 229mm, Width: 152mm,
Weight: 1.000kg
ISBN: 9780128240489
ISBN 10: 0128240482
Pages: 736
Publication Date: 23 August 2021
Audience: Professional and scholarly , Undergraduate
Format: Paperback
Publisher's Status: Active

1. Functional roles of lipids in biological membranes Mikhail Bogdanov and William Dowhan 2. Methods of lipid analysis Bebiana C. Sousa, Michael J.O. Wakelam and Andrea F. Lopez-Clavijo 3. Fatty acid and phospholipid biosynthesis in prokaryotes Jessica M. Gullett and Charles O. Rock 4. Lipid metabolism in plants Katherine M. Schmid 5. Fatty acid handling in mammalian cells Richard Lehner and Ariel D. Quiroga 6. Fatty acid desaturation and elongation in mammals Lucas M. O’Neill, Makoto Miyazaki, Laura M. Bond, Sarah A. Lewis, Fang Ding, Zhaojin Liu and James M. Ntambi 7. Phospholipid synthesis in mammalian cells Neale Ridgway 8. Phospholipid catabolism Dakai Zhang and Guangwei Du 9. Sphingolipids Anthony H. Futerman 10. Cholesterol synthesis Andrew J. Brown, Hudson W. Coates and Laura J. Sharpe 11. Structure and function of lipid droplets Hongyuan Yang and Jun Liu 12. Bile acid metabolism Jennifer K. Truong and Paul A. Dawson 13. Lipid modification of proteins Marilyn D. Resh 14. Inter- and intra-membrane lipid transport Vesa M. Olkkonen and Elina Ikonen 15. High-density lipoproteins metabolism and protective roles Valentin Blanchard and Gordon A. Francis 16. Assembly and secretion of triglyceride-rich lipoproteins Eric A. Fisher and Roger S. McLeod 17. Lipoprotein(a) Michael B. Boffa and Marlys L. Koschinsky 18. Lipoprotein receptors Kristina Kuhbandner, Joachim Herz and Theresa Pohlkamp 19. Atherosclerosis Murray W. Huff and Katey J. Rayner 20. Diabetic dyslipidaemia Khosrow Adeli, Changting Xiao, Victoria Higgins, Jennifer Taher, Sarah Farr and Gary F. Lewis

Dr. Neale Ridgway has made his scientific mark nationally and internationally and is a noted world expert in the synthesis, transport and regulation of two of the most abundant and important lipids in the human body – cholesterol and phosphatidylcholine His revelations about the signals and pathways that control these lipids are having a profound impact on our understanding of the origins and progression of such diseases as Alzheimer’s, atherosclerosis, cancer and lipid storage disorders. His groundbreaking work is frequently cited by other scientists in the literature, a key indicator of his influence and achievements. Dr. McLeod is a lipid researcher and studies how dietary fats are transported, broken down, stored and used in the body – and how different fats can either lead to, or prevent, chronic disease. He’s particularly interested in obesity, type 2 diabetes and cardiovascular disease, related diseases that are skyrocketing, in spite of widespread attempts to counter the deadly trends.