This book clearly presents the basic concepts of pharmacokinetics through graphs and simulations. Expanding on the first edition, the text covers the biological and physiological basis of the different pharmacokinetic behavior. It also contains seven new chapters with topics including bioequivalence, pharmacogenomics, pharmacokinetic basis of drug interaction, computers in pharmacokinetics, and physiological pharmacokinetic modeling and animal scale-up. In addition, the award-winning updated companion CD includes a section for pharmacokinetic simulations and pharmacodynamic simulations, aiding users interested in simulating the pharmacokinetic behavior of drugs.
Mohsen A. Hedaya (Associate Professor Kuwait University Safat)
Routledge Member of the Taylor and Francis Group
Country of Publication:
2nd New edition
Series: Pharmacy Education Series
09 February 2012
Further / Higher Education
Introduction to PharmacokineticsReview of Mathematical Fundamentals Drug Pharmacokinetics Following a Single IV Bolus Administration: Drug DistributionDrug Pharmacokinetics Following a Single IV Bolus Administration: Drug ClearanceDrug Pharmacokinetics Following a Single IV Bolus Administration: The Rate of Drug EliminationDrug Absorption Following Extravascular Administration: Biological, Physiological, and Pathological Considerations Drug Absorption Following Extravascular Administration: Molecular and Physicochemical ConsiderationsDrug Absorption Following Extravascular Administration: Formulation Factors Drug Pharmacokinetics Following Single Oral Drug Administration: The Rate of Drug Absorption Drug Pharmacokinetics Following Single Oral Drug Administration: The Extent of Drug Absorption Bioequivalence Drug Pharmacokinetics during Constant Rate IV Infusion: The Steady-State Principle Steady State during Multiple Drug Administration Renal Drug Excretion Metabolite Pharmacokinetics Nonlinear PharmacokineticsMulticompartment Pharmacokinetic ModelsDrug Pharmacokinetics Following Administration by Intermittent Intravenous Infusion Pharmacokinetic-Pharmacodynamic Modeling Noncompartmental Approach in Pharmacokinetic Data Analysis Physiological Approach to Hepatic ClearancePhysiologically Based Pharmacokinetic Models Therapeutic Drug MonitoringPharmacokinetics in Special Patient Populations Pharmacokinetic Drug-Drug InteractionsPharmacogenetics: The Genetic Basis of Pharmacokinetic and Pharmacodynamic Variability Applications of Computers in Pharmacokinetics The Companion CD Solutions for the Practice Problems Index
Mohsen A. Hedaya is Associate Professor in the Department of Pharmaceutics at Kuwait University, Safat, Kuwait.