Barcelona entwines two partners, four friends, through poignant moments based around a comma of memories both fond and harrowing. A broken timeline of their past leads to the reasoning behind Viaan, an artist struggling with a life limiting illness, tethered and unhinged relationship with her abusive partner Cole; and Byron and Jane's passionately honest and intimate connection. Each character reveals history, perceptions, and restraints placed on themselves and those around them that simultaneously effect and destroy how they live and love each other, rupturing each individual's relentless desire for freedom.