Paolo Pozzilli MD Department of Endocrinology & Diabetes, University Campus Bio-Medico di Roma, Rome, Italy; Centre of Diabetes, The Blizard Institute, St. Bartholomew's and the London School of Medicine, Queen Mary University of London, London, UK Andrea Lenzi MD Department of Experimental Medicine, Sapienza University of Rome. Policlinico Umberto I, Rome, Italy Bart L Clarke MD Division of Endocrinology, Diabetes, Metabolism and Nutrition, Mayo Clinic College of Medicine, Rochester, MN, USA William F Young Jr, MD, MSc Division of Endocrinology, Diabetes, Metabolism and Nutrition, Mayo Clinic College of Medicine, Rochester, MN, USA