Arylamine N-acetyltransferases In Health And Disease: From Pharmacogenetics To Drug Discovery And Diagnostics...

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Nicola Laurieri (University Of Oxford, Uk) Edith Sim (University Of Oxford, Uk)

Arylamine N-acetyltransferases In Health And Disease

From Pharmacogenetics To Drug Discovery And Diagnostics

Nicola Laurieri (University Of Oxford, Uk), Edith Sim (University Of Oxford, Uk)

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English

World Scientific Publishing Co Pte Ltd
27 April 2018

Pharmacology; Enzymology

Summary
Details

This book is a fascinating overview of one of the first pharmacogenetic traits to be identified as responsible for genetic variation in response to drugs - the understanding of the arylamine N-acetyltransferases (NATs) is linked to many important therapeutic areas, particularly tuberculosis and also cancer. NATs have been important in the metabolism of established anti-tubercular drugs and also in carcinogenesis and susceptibility to bladder cancer. The reach of these enzymes spans pharmacology and therapeutics as well as toxicology and pharmacogenetics. The NAT genes are encoded in a highly polymorphic region of the human genome which has been explored for fine mapping in molecular anthropological studies.

The book takes a wide ranging approach covering all aspects of the arylamine N-acetyltransferases from genetics to the chemistry and structural biology of the enzymes in the organisms in which they are found, from humans to bacteria and fungi where they appear to have distinct roles. The coverage is by experts in the field from across the globe.

Edited by: Nicola Laurieri (University Of Oxford Uk), Edith Sim (University Of Oxford, Uk)
Imprint: World Scientific Publishing Co Pte Ltd
Country of Publication: Singapore
ISBN: 9789813232006
ISBN 10: 9813232005
Pages: 456
Publication Date: 27 April 2018
Audience: College/higher education , Professional and scholarly , Primary , Undergraduate
Format: Hardback
Publisher's Status: Active