Animal Models of Dementia

Peter Paul De Deyn, Debby Van Dam

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English

Humana Press Inc.
01 December 2010

Neurosciences; Animal pathology & diseases

Series: Neuromethods

With an ever-increasing elderly population and the resultant rising levels of dementia-related disorders, preclinical research based on animal models is pivotal to our knowledge of underlying molecular mechanisms and drug discovery aiming at the development of therapeutic strategies alleviating or preventing the neurological devastation.

In Animal Models of Dementia, expert researchers provide contributions that stress the importance of extensively validated animal models in drug discovery and development in order to predict clinical activity.

Beginning with general aspects of animal modeling, related ethical issues, and essential methodological considerations, the highly detailed volume then continues with various levels of model validation, including pathological, behavioral, neurochemical, pharmacological, and imaging aspects, followed by sections focused on specific disorders, such as Alzheimer’s disease, Parkinson’s disease, metachromatic leukodystrophy and adrenoleukodystrophy, amyotrophic lateral sclerosis, frontotemporal dementia as well as vascular dementia and more.

As a volume in the renowned Neuromethods series, this book offers a detailed, yet accessible, overview of currently available animal models in the field of dementia research, and touches, as well, upon more general areas linked to the development and use of animal models.

Comprehensive and efficient, Animal Models of Dementia will significantly aid both experienced animal researchers as well as investigators on the verge of beginning animal model-based dementia research.

Edited by: Peter Paul De Deyn, Debby Van Dam
Imprint: Humana Press Inc.
Country of Publication: United States
Edition: 2011
Volume: 48
Dimensions: Height: 254mm, Width: 178mm, Spine: 39mm
Weight: 3.320kg
ISBN: 9781607618973
ISBN 10: 1607618974
Series: Neuromethods
Pages: 732
Publication Date: 01 December 2010
Audience: Professional and scholarly , Undergraduate
Format: Hardback
Publisher's Status: Active

Reviews for Animal Models of Dementia

"From the reviews: ""A great add-on to more basic textbooks on mechanisms of dementia. The book not only nicely summarizes ongoing efforts to model dementia but also describes how to investigate underlying mechanisms at various level of complexity. ... Importantly, leading mouse models are discussed, which is very useful for newcomers to the field, as there are a lot of different models. ... Additionally, the book provides information about ethics on animal experimentation and information on intellectual property, issues that can be rarely found in textbooks."" (Karl Peter Giese, British Journal of Clinical Pharmacology, May, 2011)"