This book synthesizes the major research advances in molecular, biochemical and translational aspects of aging and heart failure over the last four decades and addresses future directions in management and drug discovery. It presents clinical issues and molecular mechanisms related to heart failure, including the changing demographics in the aging population with heart failure; hypertension and prevention of diastolic heart failure in the aging population; polypharmacy and adverse drug reactions in the aging population with heart failure; changes in the heart that accompany advancing age from humans to molecules; aging-associated alterations in myocardial inflammation and fibrosis and aging-related changes in mitochondrial function and implications for heart failure therapy. The book succinctly summarizes the large volume of data on these key topics and highlights novel pathways that need to be explored. Featuring contributions from leading clinician-scientists, Aging and Heart Failure: Mechanisms and Management is an authoritative resource on the major clinical issues in heart failure therapy in the elderly for cardiologists, gerontologists and internists.
Edited by:
Bodh I. Jugdutt
Imprint: Springer-Verlag New York Inc.
Country of Publication: United States
Dimensions:
Height: 254mm,
Width: 178mm,
Spine: 33mm
Weight: 1.221kg
ISBN: 9781493902675
ISBN 10: 1493902679
Pages: 475
Publication Date: 21 February 2014
Audience:
Professional and scholarly
,
Undergraduate
Format: Hardback
Publisher's Status: Active
Ch. 1: Changing demographics of the aging population with heart failure and implications for therapy Bodh I. Jugdutt Ch. 2: Biology of aging and implications for heart failure therapy and prevention Bodh I. Jugdutt Ch. 3: Hypertension and prevention of diastolic heart failure in the aging population Wilbert S. Aronow Maciej Banach Ali Ahmed Ch. 4: Aging and optimal therapy of systolic heart failure in the elderly Nakul Chander Sharma Bodh I. Jugdutt Ch. 5: Atrial fibrillation and heart failure in the aging population Pedram Kazemian Bodh I. Jugdutt Ch. 6: Optimizing therapy of heart failure in the aging population with monitoring in clinics John R. Dimitry Justin A. Ezekowitz Ch. 7: Cardiac alterations in aging, hypertension and diastolic heart failure Edith Pituskin D. Ian Paterson Ch. 8: Polypharmacy and adverse drug reactions in the aging population with heart failure Michael W. Rich William J. Nienaber Ch. 9: Aging-related changes in vascular biology and implications for heart failure therapy in the aging population Michael Sean McMurtry Ch. 10: Biomarkers and optimal management of heart failure in the aging population Hanna K. Gaggin James L. Januzzi, Jr. Ch. 11: Benefits of Exercise in the elderly Ezra A. Amsterdam C. Tissa Kappagoda Ch. 12: The RAAS in heart failure: an update on clinical trials and opportunities for therapy C. Tissa Kappagoda Ezra A. Amsterdam Ch. 13: Aging and diastolic dysfunction - the interplay of inflammation and extracellular matrix regulation Peter Moritz Becher Dirk Westermann, Carsten Tschoepe Ch. 14: Reperfusion and vasodilator therapy in elderly patients with STEMI and heart failure. Improving outcomes Bodh I. Jugdutt, Anwar Jelani Seraj Abualnaja Nakul Chander Sharma Joseph Szeman Wong Ch. 15: Erythropoietin therapy for heart failure Margarita Borovka Mathew S. Maurer Ch. 16: Role of resistin in heart failure in the elderly Yasuchika Takeishi Ch. 17: Role of coronary artery calcium in cardiovascular risk stratification and management in the aging population Craig R. Butler Paolo Raggi Ch. 18: Aging-and remodeling of the RAS and RAAS and related pathways. Implications for heart failure therapy Bodh I. Jugdutt Ch. 19: Aging and right ventricular failure from pulmonary hypertension: Effect of right ventricular and pulmonary artery remodeling Joseph Szeman Wong Bodh I. Jugdutt Ch. 20: Biomarkers of cardiovascular aging Nirankar S. Neki Paramjit S. Tappia Naranjan S. Dhalla Ch. 21: Changes in the heart that accompany advancing age: Humans to molecules Edward G. Lakatta Harold A. Spurgeon Andzej M. Janczewski Ch. 22: Aging-related changes in cell death and cell survival pathways and implications for heart failure therapy Guido R.Y. De Meyer Dorien M. Schrijvers Wim Martinet Ch. 23: Aging-related changes in telomeres and telomerases and implications for heart failure therapy Pim van der Harst Dirk J. van Veldhuisen Ch. 24: Aging associated alterations in myocardial inflammation and fibrosis: pathophysiological perspectives and clinical implications Arti V. Shinde Nikolaos G Frangogiannis Ch. 25: Aging-related changes in extracellular matrix: implications for ventricular remodeling following myocardial infarction Nguyen T. Nguyen Andriy Yabluchanskiy Lisandra E. de Castro Bras Yu-Fang Jin Merry L. Lindsey Ch. 26: Calcium handling defects and changes in cardiac function in the aging heart Adriana Adameova Nirankar S. Neki Paramjit S. Tappia Naranjan S. Dhalla Ch. 27: Integrins: Implications for aging in heart failure therapy Laura L. Daniel William L. Joyner Mahipal Singh Krishna Singh Ch. 28: Adipokines as novel biomarkers in aging and heart failure Ken Shinmura Ch. 29: Aging-related changes in cellular and molecular mechanisms of post-infarction remodeling. Implications for heart failure therapy Henry Han-Jen Shih Andrew J. Boyle Ch. 30: Aging-related changes in mitochondrial function and implication for heart failure therapy Satoaki Matoba Atsushi Hoshino Hiroaki Matsubara Ch. 31: Regulation of SERCA via oxidative modifications: Implications for the pathophysiology of diastolic dysfunction in the aging heart Fuzhong Qin Richard A. Cohen Wilson S. Colucci Ch. 32: SMP-30 and aging-related cardiac remodeling and heart failure Satoshi Suzuki Yasuchika Takeishi
Reviews for Aging and Heart Failure: Mechanisms and Management
From the reviews: This book details the clinical, physiological, and molecular aspects of heart failure pathophysiology, diagnosis, and management. ... The book caters mainly to advanced care practitioners in adult cardiovascular disease and primary care, including physicians, physician assistants, and nurse practitioners. Investigators with an interest in the molecular changes of the aging cardiovascular system also would benefit from this book. Finally, nurses who are part of a heart failure team or care for patients with cardiovascular complications will find it useful. (Shawn Ragbir, Doody's Book Reviews, June, 2014)
